Molecular structure of (3S,6R)-Lateritin, CAS Number: 65454-13-9
(3S,6R)-Lateritin (CAS 65454-13-9)
Alternate Names:
Antibiotic PI290
Application:
(3S,6R)-Lateritin is (3S,6R)-Lateritin is an Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor
CAS Number:
65454-13-9
Purity:
≥97%
Molecular Weight:
261.3
Molecular Formula:
C15H19NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
(3S,6R)-Lateritin is an N-methylated peptide that is structurally equivalent to a monomer of beauvericin, It is an Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor.
(3S,6R)-Lateritin (CAS 65454-13-9) References
- Total synthesis of bassiatin and its stereoisomers: novel divergent behavior of substrates in Mitsunobu cyclizations. | Hughes, AB. and Sleebs, MM. 2005. J Org Chem. 70: 3079-88. PMID: 15822967
- A novel antioestrogen agent (3R,6R)-bassiatin inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression in 17β-oestradiol-treated MCF-7 cells. | Meng, L., et al. 2011. Cell Biol Int. 35: 599-605. PMID: 21241249
- ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. | Meng, L., et al. 2012. Cell Biol Int. 36: 345-8. PMID: 22150072
- Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity. | Huang, LH., et al. 2017. Molecules. 22: PMID: 28287456
- Isolation, purification and identification of biological compounds from Beauveria sp. and their evaluation as insecticidal effectiveness against Bemisia tabaci. | An, R., et al. 2021. Sci Rep. 11: 12020. PMID: 34103637
- The regulation of BbLaeA on the production of beauvericin and bassiatin in Beauveria bassiana. | Yin, M., et al. 2021. World J Microbiol Biotechnol. 38: 1. PMID: 34817662
- Genomic and Experimental Analysis of the Insecticidal Factors Secreted by the Entomopathogenic Fungus Beauveria pseudobassiana RGM 2184. | Altimira, F., et al. 2022. J Fungi (Basel). 8: PMID: 35330256
- Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. | Hasumi, K., et al. 1993. J Antibiot (Tokyo). 46: 1782-7. PMID: 8294234
- Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717. | Kagamizono, T., et al. 1995. J Antibiot (Tokyo). 48: 1407-12. PMID: 8557595
Inhibitor of:
ACAT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(3S,6R)-Lateritin, 1 mg | sc-364092 | 1 mg | $214.00 |