3,5-Difluoro-2-(trifluoromethyl)pyridine
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SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGF-β (transforming growth factor-β) superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7. Renal carcinoma studies have demonstrated that SB 431542 is a selective inhibitor of Smad3 phosphorylation (IC50= 94nM) and TGF-β-1 collagen induced lα1 (col Iα1). It has been reported that SB 431542 does not affect the JNK, ERK, or p38 MAP kinase pathways. SB 431542 may act to suppress TGF-β induced growth stimulation in MG63 cells, inhibit the motility and proliferation of glioma cells, and block the phosphorylation and translocation of SMADs. SB 431542 is also known as 4-[4-(1,3-Benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide, TGF-β RI Kinase Inhibitor VI, and ALK inhibitor.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,5-Difluoro-2-(trifluoromethyl)pyridine, 1 g | sc-313687 | 1 g | $270.00 |