Date published: 2025-12-16

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3,5-Di-tert-butyl-4-hydroxybenzoic acid (CAS 1421-49-4)

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CAS Number:
1421-49-4
Molecular Weight:
250.33
Molecular Formula:
C15H22O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,5-Di-tert-butyl-4-hydroxybenzoic acid (DTBA) is a compound that occurs naturally in various sources but is also synthesized. It presents as a white crystalline solid. Scientific research extensively employs 3,5-Di-tert-butyl-4-hydroxybenzoic acid due to its diverse applications. It functions as a reagent in organic synthesis and serves as useful for studying the role of free radicals in biological systems.


3,5-Di-tert-butyl-4-hydroxybenzoic acid (CAS 1421-49-4) References

  1. Infrared and Raman Spectra of a Single Resin Bead for Analysis of Solid-Phase Reactions and Use in Encoding Combinatorial Libraries.  |  Rahman, SS., et al. 1998. J Org Chem. 63: 6196-6199. PMID: 11672249
  2. The metabolism of 3:5-di-tert.-butyl-4-hydroxytoluene and 3:5-di-tert.-butyl-4-hydroxybenzoic acid in the rabbit.  |  Dacre, JC. 1961. Biochem J. 78: 758-66. PMID: 16748891
  3. The metabolism of 2,6-di-tert.-butyl-4-hydroxymethylphenol (Ionox 100) in the dog and rat.  |  Wright, AS., et al. 1965. Biochem J. 97: 303-10. PMID: 16749118
  4. Phenol-based lipophilic fluorescent antioxidant indicators: a rational approach.  |  Krumova, K., et al. 2009. J Org Chem. 74: 3641-51. PMID: 19364120
  5. Novel compounds designed as antistress agents.  |  Tsiakitzis, KC., et al. 2009. J Med Chem. 52: 7315-8. PMID: 19863055
  6. Further metabolism of 3,5-di-tert-butyl-4-hydroxybenzoic acid, a major metabolite of butylated hydroxytoluene, in rats.  |  Yamamoto, K., et al. 1991. Chem Pharm Bull (Tokyo). 39: 512-4. PMID: 2054880
  7. Bismuth-based cyclic synthesis of 3,5-di-tert-butyl-4-hydroxybenzoic acid via the oxyarylcarboxy dianion, (O2CC6H2(t)Bu2O)2-.  |  Kindra, DR. and Evans, WJ. 2014. Dalton Trans. 43: 3052-4. PMID: 24336959
  8. Synthesis of new 2,5-di-substituted 1,3,4-oxadiazoles bearing 2,6-di-tert-butylphenol moieties and evaluation of their antioxidant activity.  |  Shakir, RM., et al. 2014. Molecules. 19: 3436-49. PMID: 24658568
  9. Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties.  |  Theodosis-Nobelos, P., et al. 2017. Bioorg Med Chem Lett. 27: 4800-4804. PMID: 29017787
  10. Design of Multifaceted Antioxidants: Shifting towards Anti-Inflammatory and Antihyperlipidemic Activity.  |  Tzara, A., et al. 2021. Molecules. 26: PMID: 34443516
  11. Genome and Metabolome MS-Based Mining of a Marine Strain of Aspergillus affinis.  |  Gonçalves, MFM., et al. 2021. J Fungi (Basel). 7: PMID: 34947073
  12. The metabolism of 3,5-di-tert.-butyl-4-hydroxytoluene in the rat and in man.  |  Daniel, JW., et al. 1968. Biochem J. 106: 783-90. PMID: 5637363
  13. The fate of di-(3,5-di-tert.-butyl-4-hydroxyphenyl)methane (Ionox 22) in the rat.  |  Wright, AS., et al. 1966. Biochem J. 99: 146-54. PMID: 5965331
  14. The metabolism of di-(3,5-di-tert.-butyl-4-hydroxybenzyl) ether (Ionox 201) in the rat.  |  Wright, AS., et al. 1967. Biochem J. 102: 351-61. PMID: 6030293

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,5-Di-tert-butyl-4-hydroxybenzoic acid, 10 g

sc-238681
10 g
$41.00