Date published: 2025-9-12

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3,5,6-Trichloro-2-pyridinol (CAS 6515-38-4)

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Alternate Names:
2-Hydroxy-3,5,6-trichloropyridine
CAS Number:
6515-38-4
Molecular Weight:
198.43
Molecular Formula:
C5H2Cl3NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,5,6-Trichloro-2-pyridinol (TCP) is a synthetic compound extensively utilized in scientific research for various applications. As a chlorinated derivative of the naturally occurring pyridine molecule, it has found its place in multiple areas of study, particularly in biochemistry. Researchers have harnessed 3,5,6-Trichloro-2-pyridinol′s potential in diverse investigations, encompassing enzyme inhibition and the effects of xenobiotics on the environment. While 3,5,6-Trichloro-2-pyridinol′s applications have been widespread, its precise mechanism of action continues to elude complete comprehension. Nevertheless, it is thought to function as an inhibitor for several enzymes, including cytochrome P450, cytochrome c oxidase, and aldehyde oxidase. Moreover, research has revealed its capacity to impede the formation of harmful reactive oxygen species, thereby safeguarding cells and tissues. Intriguingly, despite its extensive use, certain aspects of 3,5,6-Trichloro-2-pyridinol, such as the synthesis method, its full biochemical effects, along with its advantages and limitations for lab experiments, are still subjects under active exploration.


3,5,6-Trichloro-2-pyridinol (CAS 6515-38-4) References

  1. Analysis of 3,5,6-trichloro-2-pyridinol in urine samples from the general population using gas chromatography-mass spectrometry after steam distillation and solid-phase extraction.  |  Koch, HM. and Angerer, J. 2001. J Chromatogr B Biomed Sci Appl. 759: 43-9. PMID: 11499628
  2. Biodegradation of chlorpyrifos and 3,5,6-trichloro-2-pyridinol by Cupriavidus sp. DT-1.  |  Lu, P., et al. 2013. Bioresour Technol. 127: 337-42. PMID: 23131657
  3. Predictors of urinary levels of 2,4-dichlorophenoxyacetic acid, 3,5,6-trichloro-2-pyridinol, 3-phenoxybenzoic acid, and pentachlorophenol in 121 adults in Ohio.  |  Morgan, MK. 2015. Int J Hyg Environ Health. 218: 479-88. PMID: 25891895
  4. Photochemical fate and photocatalysis of 3,5,6-trichloro-2-pyridinol, degradation product of chlorpyrifos.  |  Žabar, R., et al. 2016. Chemosphere. 144: 615-20. PMID: 26398927
  5. Degradation of 3,5,6-trichloro-2-pyridinol by a microbial consortium in dryland soil with anaerobic incubation.  |  Wang, S., et al. 2019. Biodegradation. 30: 161-171. PMID: 30929106
  6. NanoFe3O4 accelerates anoxic biodegradation of 3, 5, 6-trichloro-2-pyridinol.  |  Zhang, C., et al. 2019. Chemosphere. 235: 185-193. PMID: 31255759
  7. Biochar amendment effectively reduces the transport of 3,5,6-trichloro-2-pyridinol (a main degradation product of chlorpyrifos) in purple soil: Experimental and modeling.  |  Lei, W., et al. 2020. Chemosphere. 245: 125651. PMID: 31881382
  8. Acute toxicity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol alone and in combination using a battery of bioassays.  |  Echeverri-Jaramillo, G., et al. 2020. Environ Sci Pollut Res Int. 27: 32770-32778. PMID: 32519098
  9. Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators.  |  Echeverri-Jaramillo, G., et al. 2021. Ecotoxicology. 30: 104-117. PMID: 33249537
  10. Novel degradation pathways for Chlorpyrifos and 3, 5, 6-Trichloro-2-pyridinol degradation by bacterial strain Bacillus thuringiensis MB497 isolated from agricultural fields of Mianwali, Pakistan.  |  Ambreen, S. and Yasmin, A. 2021. Pestic Biochem Physiol. 172: 104750. PMID: 33518043
  11. 3,5,6-trichloro-2-pyridinol intensifies the effect of chlorpyrifos on the paracrine function of Sertoli cells by preventing binding of testosterone and the androgen receptor.  |  Gao, H., et al. 2021. Toxicology. 460: 152883. PMID: 34352351
  12. The Role of CYP2B6*6 Gene Polymorphisms in 3,5,6-Trichloro-2-pyridinol Levels as a Biomarker of Chlorpyrifos Toxicity Among Indonesian Farmers.  |  Liem, JF., et al. 2022. J Prev Med Public Health. 55: 280-288. PMID: 35678002
  13. 3,5,6-Trichloro-2-pyridinol confirms ototoxicity in mouse cochlear organotypic cultures and induces cytotoxicity in HEI-OC1 cells.  |  Huang, M., et al. 2023. Toxicol Appl Pharmacol. 116612. PMID: 37463651

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,5,6-Trichloro-2-pyridinol, 100 mg

sc-238708
100 mg
$40.00