Date published: 2025-11-23

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3,3-Dimethylbutyryl chloride (CAS 7065-46-5)

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Alternate Names:
tert-Butylacetyl chloride
Application:
3,3-Dimethylbutyryl chloride is an acyl chloride compound for proteomics research
CAS Number:
7065-46-5
Molecular Weight:
134.60
Molecular Formula:
C6H11ClO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,3-Dimethylbutyryl chloride is a versatile acylating agent utilized in organic synthesis to introduce the 3,3-dimethylbutyryl group into a variety of organic molecules. This chemical plays a role as a fundamental building block in the assembly of complex organic structures, enhancing the molecular diversity needed for advanced research in chemistry and materials science. The efficacy of 3,3-Dimethylbutyryl chloride stems from its mechanism of action, which involves the acylation of nucleophilic groups including alcohols, amines, and thiols. This process is facilitated through the formation of an acyl intermediate, enabling the efficient transfer of the acyl group to these nucleophiles. The reactive chloride atom in the compound is pivotal, as it forms a highly electrophilic carbonyl carbon upon interaction with the target molecule, promoting the subsequent nucleophilic attack.


3,3-Dimethylbutyryl chloride (CAS 7065-46-5) References

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  4. Intramolecular phenoxymercuration of 2-allylphenols. Regioselectivity and stereochemistry  |  Takahiro Hosokawa, Shyogo Miyagi, Shunichi Murahashi, Akio Sonoda, Yoshiki Matsuura, Shigeki Tanimoto, and Masao Kakudo. 1978. J. Org. Chem. 43: 719–724.
  5. Synthesis of Pd(II) coordination complexes of (S)-4-isobutyl-2-methyl-2-oxazoline and (S)-2-(2,2-dimethylpropyl)-4-isopropyl-2-oxazoline  |  Relindis Y. Mawo, Diane M. Johnson, Irina P. Smoliakova. 2008. Inorganic Chemistry Communications. 11: 1397-1400.
  6. Dehydrochlorination of Carboxylic Acid Chlorides by an Aluminum/Phosphorus-Based Frustrated Lewis Pair and the Formation of Ketene Adducts  |  Werner Uhl, Philipp Wegener, Ernst-Ulrich Würthwein. 2015. 641: 2102-2108.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,3-Dimethylbutyryl chloride, 25 g

sc-238636
25 g
$78.00