![3-[(3-Diethylamino-propylamino)-methyl]-7-methyl-1H-quinolin-2-one - chemical structure image](https://media.scbt.com/product/3--3-diethylamino-propylamino-methyl-7-methyl-1h-quinolin-2-one-structure_22_82_b_228231.jpg)
![3-[(3-Diethylamino-propylamino)-methyl]-7-methyl-1H-quinolin-2-one - chemical structure image](https://media.scbt.com/product/3--3-diethylamino-propylamino-methyl-7-methyl-1h-quinolin-2-one-structure_22_82_t_228231.jpg "Molecular structure of 3-[(3-Diethylamino-propylamino)-methyl]-7-methyl-1H-quinolin-2-one")
3-[(3-Diethylamino-propylamino)-methyl]-7-methyl-1H-quinolin-2-one
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HDAC6 Inhibitor, also known as CAY10603 is a selective and potent inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with HDAC1 (IC50 = 271 nM), HDAC2 (IC50 = 252 nM), HDAC3 (IC50 = 0.42 nM), HDAC8 (IC50 = 6851 nM), and HDAC10 (IC50 = 90.7 nM). In comparison, its inhibitory activity against other HDAC isoforms (HDAC1, 2, 3, 8, and 10) is significantly weaker, with IC50 values of 271, 252, 0.42, 6851, and 90.7 nM, respectively. It also prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 muM). HDAC6 Inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroamic acid (sc-220139). HDAC6 Inhibitor is a specific class II HDAC enzyme that plays a role in transcription repression by removing acetyl groups from histones. It also deacetylates tubulin, a protein for regulating microtubule stability and function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(3-Diethylamino-propylamino)-methyl]-7-methyl-1H-quinolin-2-one, 500 mg | sc-312067 | 500 mg | $285.00 |