Molecular structure of 2′-O-Methyl Guanosine, CAS Number: 2140-71-8
2′-O-Methyl Guanosine (CAS 2140-71-8)
Application:
2′-O-Methyl Guanosine is a Guanosine analog
CAS Number:
2140-71-8
Molecular Weight:
297.27
Molecular Formula:
C11H15N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
2′-O-Methyl Guanosine is in molecular biology, especially in studies focused on RNA stability and dynamics. This modified nucleoside is critical for exploring the structural properties of RNA, such as its resistance to enzymatic degradation and its ability to form stable duplexes with complementary RNA or DNA. Some employ 2′-O-Methyl Guanosine to understand its impact on the thermal stability of nucleic acid complexes, which is used for deciphering RNA interactions and function. 2′-O-Methyl Guanosine is utilized in investigations related to RNA interference mechanisms, helping to clarify the role of modifications in RNA-mediated gene regulation.
2′-O-Methyl Guanosine (CAS 2140-71-8) References
- Detection in HeLa cell extracts of a 7-methyl guanosine specific enzyme activity that cleaves m7GpppNm. | Nuss, DL., et al. 1975. Cell. 6: 21-7. PMID: 1164732
- Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs. | Kuwasaki, T., et al. 2003. J Antimicrob Chemother. 51: 813-9. PMID: 12654739
- MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines. | Chow, S., et al. 2003. Nucleosides Nucleotides Nucleic Acids. 22: 583-7. PMID: 14565233
- Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. | Jackson, AL. and Linsley, PS. 2010. Nat Rev Drug Discov. 9: 57-67. PMID: 20043028
- Staying on message: design principles for controlling nonspecific responses to siRNA. | Samuel-Abraham, S. and Leonard, JN. 2010. FEBS J. 277: 4828-36. PMID: 21078117
- Guanosine modifications in runoff transcripts of synthetic transfer RNA-Phe genes microinjected into Xenopus oocytes. | Grosjean, H., et al. 1990. Biochim Biophys Acta. 1050: 267-73. PMID: 2207154
- 2'-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA. | Balasubramaniyam, T., et al. 2018. Molecules. 23: PMID: 30304782
- Stability and properties of Z-DNA containing artificial nucleobase 2'-O-methyl-8-methyl guanosine. | Balasubramaniyam, T., et al. 2019. Bioorg Med Chem. 27: 364-369. PMID: 30545733
- Protein-induced B-Z transition of DNA duplex containing a 2'-OMe guanosine. | Jin, HS., et al. 2020. Biochem Biophys Res Commun. 533: 417-423. PMID: 32972754
- An analytical method for the separation of sugar-methylated ribonucleosides from base-methylated and nonmethylated ribonucleosides. | al-Arif, A. and Sporn, MB. 1972. Anal Biochem. 48: 386-93. PMID: 4341766
- Selective modification of nucleosides of tRNA precursors accumulated in a temperature sensitive mutant of Escherichia coli. | Sakano, H., et al. 1974. FEBS Lett. 48: 117-21. PMID: 4609799
- Preparation and specificity of antibodies directed toward the ribose methylated nucleotide, 2'-O-methylguanosine 5'-monophosphate. | Vold, BS. 1981. Biochim Biophys Acta. 655: 265-7. PMID: 6269628
Inhibitor of:
RNA Polymerase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′-O-Methyl Guanosine, 500 mg | sc-220822 | 500 mg | $180.00 |