2′,3′-O-Isopropylideneinosine (CAS 2140-11-6)

2′,3′-O-Isopropylideneinosine is a modified nucleoside that features a protective isopropylidene group bonded to the hydroxyl groups on the 2′ and 3′ positions of the ribose sugar in inosine. This structural modification enhances the molecule′s stability, making it resistant to enzymatic and chemical breakdown, which is essential for various research applications, particularly in the synthesis of more complex nucleosides and RNA-related studies. Researchers utilize this compound primarily as an intermediate in creating novel nucleic acid analogs and in exploring RNA functionalities. The protective groups ensure that the nucleoside can be manipulated without degradation, which is pivotal in experiments focusing on the synthesis and behavior of modified RNA molecules. These investigations are crucial for understanding RNA′s structural properties, its interactions within biological systems, and the potential for RNA-based innovations in biotechnology. By facilitating the stable integration of modified nucleosides into RNA sequences, 2′,3′-O-Isopropylideneinosine plays a significant role in advancing the field of molecular biology, contributing to the broader exploration of genetic engineering and therapeutic research without direct clinical application.