Molecular structure of 24-Hydroxycholesterol
24-Hydroxycholesterol (CAS 30271-38-6)
Alternate Names:
Cholest-5-ene-3β,24-diol; (3β)-Cholest-5-ene-3,24-diol
Application:
24-Hydroxycholesterol is 24-Hydroxycholesterol a main cholesterol elimination product of the brain
CAS Number:
30271-38-6
Molecular Weight:
402.65
Molecular Formula:
C27H46O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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24-Hydroxycholesterol a main cholesterol elimination product of the brain. 24-Hydroxycholesterol acts on a variety of cellular processes, including cholesterol metabolism, inflammation, and cell death. In addition, 24-Hydroxycholesterol may act to modulate the activity of certain transcription factors, which may affect gene expression. Finally, 24-Hydroxycholesterol has been found to interact with certain receptors, such as the nuclear receptor LXRα, which may be involved in the regulation of cholesterol metabolism.
24-Hydroxycholesterol (CAS 30271-38-6) References
- Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | Li-Hawkins, J., et al. 2000. J Biol Chem. 275: 16543-9. PMID: 10748047
- 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | Norlin, M., et al. 2000. J Lipid Res. 41: 1629-39. PMID: 11013305
- Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. | Kölsch, H., et al. 2001. J Neural Transm (Vienna). 108: 475-88. PMID: 11475014
- Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | Prasanthi, JR., et al. 2009. Mol Neurodegener. 4: 1. PMID: 19126211
- Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. | Fourgeux, C., et al. 2009. Invest Ophthalmol Vis Sci. 50: 5712-7. PMID: 19553612
- 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. | Cook, IT., et al. 2009. Drug Metab Dispos. 37: 2069-78. PMID: 19589875
- Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | Gamba, P., et al. 2011. Aging Cell. 10: 403-17. PMID: 21272192
- Lecithin-cholesterol acyltransferase in brain: Does oxidative stress influence the 24-hydroxycholesterol esterification? | La Marca, V., et al. 2016. Neurosci Res. 105: 19-27. PMID: 26454063
- Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. | Wang, HL., et al. 2016. J Alzheimers Dis. 51: 45-55. PMID: 26836015
- Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders. | Grayaa, S., et al. 2018. Biochimie. 153: 80-85. PMID: 29730299
- A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. | Testa, G., et al. 2018. Redox Biol. 17: 423-431. PMID: 29883958
- Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. | Zhang, J., et al. 1997. Biochem J. 322 (Pt 1): 175-84. PMID: 9078259
- The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells. | Kölsch, H., et al. 1999. Brain Res. 818: 171-5. PMID: 9914453
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
24-Hydroxycholesterol, 10 mg | sc-489589 | 10 mg | $380.00 |