Date published: 2025-10-21

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2-(Trifluoromethyl)aniline (CAS 88-17-5)

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Alternate Names:
α,α,α-Trifluoro-o-toluidine; 2-Aminobenzotrifluoride
CAS Number:
88-17-5
Molecular Weight:
161.12
Molecular Formula:
C7H6F3N
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(Trifluoromethyl)aniline is a chemical compound that functions as a building block in organic synthesis. It acts as a precursor in the production of various agrochemicals, and other fine chemicals. 2-(Trifluoromethyl)Aniline undergoes substitution reactions, allowing for the introduction of the trifluoromethyl group into organic molecules. Through its mechanism of action, 2-(Trifluoromethyl)aniline participates in nucleophilic aromatic substitution reactions, enabling the synthesis of complex organic compounds with specific functional groups. 2-(Trifluoromethyl)Aniline′s role in the experimental involves its ability to facilitate the creation of diverse molecular structures, contributing to the development of new materials and compounds for industrial applications. Its mechanism of action involves its reactivity in organic synthesis, allowing for the modification and functionalization of organic molecules to generate novel chemical entities.


2-(Trifluoromethyl)aniline (CAS 88-17-5) References

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  3. Bioactive Thiazine and Benzothiazine Derivatives: Green Synthesis Methods and Their Medicinal Importance.  |  Badshah, SL. and Naeem, A. 2016. Molecules. 21: PMID: 27537865
  4. Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.  |  Cioffi, CL., et al. 2020. J Med Chem. 63: 11054-11084. PMID: 32878437
  5. Influence of inter- and intramolecular H-bonding on the mesomorphic and photoswitching behaviour of (E)-4-((4-(hexyloxy)phenyl)diazenyl)-N-phenyl benzamides.  |  Sunil, BN., et al. 2020. RSC Adv. 10: 20222-20230. PMID: 35520455
  6. Recent Advances in Asymmetric Synthesis of Pyrrolidine-Based Organocatalysts and Their Application: A 15-Year Update.  |  Quintavalla, A., et al. 2023. Molecules. 28: PMID: 36903480
  7. A novel imidazole-based azo molecule: synthesis, characterization, quantum chemical calculations, molecular docking, molecular dynamics simulations and ADMET properties.  |  Karabacak Atay, Ç., et al. 2023. J Mol Model. 29: 226. PMID: 37405575

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(Trifluoromethyl)aniline, 5 g

sc-237884
5 g
$28.00

2-(Trifluoromethyl)aniline, 100 g

sc-237884A
100 g
$61.00