Molecular structure of 2-Keto-L-gulonic Acid, CAS Number: 526-98-7
2-Keto-L-gulonic Acid (CAS 526-98-7)
Alternate Names:
L-Xylo-2-Hexulosonic Acid
Application:
2-Keto-L-gulonic Acid is used to study sorbitol metabolism by Acetobacter melanogenus.
CAS Number:
526-98-7
Purity:
≥89%
Molecular Weight:
194.14
Molecular Formula:
C6H10O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Keto-L-gulonic Acid (2KLG) is an important intermediate in the biosynthesis of ascorbic acid (vitamin C) used to study sorbitol metabolism by Acetobacter melanogenus. The enzyme glucose dehydrogenase catalyzes the oxidation of glucose to 2-Keto-L-gulonic Acid, which is then converted to ascorbic acid by the action of the enzyme L-gulonolactone oxidase. 2-Keto-L-gulonic Acid has anti-inflammatory and antioxidant effects. It has been used in the study of vitamin C metabolism, as well as in the study of cellular processes, such as glycolysis and oxidative phosphorylation.
2-Keto-L-gulonic Acid (CAS 526-98-7) References
- Taxonomic characterization of Ketogulonigenium vulgare gen. nov., sp. nov. and Ketogulonigenium robustum sp. nov., which oxidize L-sorbose to 2-keto-L-gulonic acid. | Urbance, JW., et al. 2001. Int J Syst Evol Microbiol. 51: 1059-1070. PMID: 11411674
- New mechanisms for the biosynthesis and metabolism of 2-keto-L-gulonic acid in bacteria. | Makover, S., et al. 1975. Biotechnol Bioeng. 17: 1485-1514. PMID: 1182275
- Production of 2-Keto-l-Gulonic Acid from d-Glucose by Two-Stage Fermentation. | Sonoyama, T., et al. 1982. Appl Environ Microbiol. 43: 1064-9. PMID: 16346005
- Continuous 2-Keto-L-gulonic acid fermentation by mixed culture of Ketogulonicigenium vulgare DSM 4025 and Bacillus megaterium or Xanthomonas maltophilia. | Takagi, Y., et al. 2010. Appl Microbiol Biotechnol. 86: 469-80. PMID: 19902207
- Comprehensive quality evaluation of corn steep liquor in 2-keto-L-gulonic acid fermentation. | Gao, Y. and Yuan, YJ. 2011. J Agric Food Chem. 59: 9845-53. PMID: 21793578
- Genetic engineering of Ketogulonigenium vulgare for enhanced production of 2-keto-L-gulonic acid. | Cai, L., et al. 2012. J Biotechnol. 157: 320-5. PMID: 22192513
- Sporulation and spore stability of Bacillus megaterium enhance Ketogulonigenium vulgare propagation and 2-keto-L-gulonic acid biosynthesis. | Zhu, Y., et al. 2012. Bioresour Technol. 107: 399-404. PMID: 22257860
- Stepwise metabolic engineering of Gluconobacter oxydans WSH-003 for the direct production of 2-keto-L-gulonic acid from D-sorbitol. | Gao, L., et al. 2014. Metab Eng. 24: 30-7. PMID: 24792618
- Production of 2-keto-L-gulonic acid by metabolically engineered Escherichia coli. | Zeng, W., et al. 2020. Bioresour Technol. 318: 124069. PMID: 32916460
- Identification of Gradient Promoters of Gluconobacter oxydans and Their Applications in the Biosynthesis of 2-Keto-L-Gulonic Acid. | Chen, Y., et al. 2021. Front Bioeng Biotechnol. 9: 673844. PMID: 33898410
- Construction of synthetic microbial consortia for 2-keto-L-gulonic acid biosynthesis. | Wang, Y., et al. 2022. Synth Syst Biotechnol. 7: 481-489. PMID: 34977392
- Combined evolutionary and metabolic engineering improve 2-keto-L-gulonic acid production in Gluconobacter oxydans WSH-004. | Li, D., et al. 2022. Bioresour Technol. 354: 127107. PMID: 35381333
- Combined engineering of l-sorbose dehydrogenase and fermentation optimization to increase 2-keto-l-gulonic acid production in Escherichia coli. | Li, D., et al. 2023. Bioresour Technol. 372: 128672. PMID: 36702324
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Keto-L-gulonic Acid, 250 mg | sc-488772A | 250 mg | $245.00 | |||
2-Keto-L-gulonic Acid, 1 g | sc-488772 | 1 g | $336.00 | |||
2-Keto-L-gulonic Acid, 5 g | sc-488772B | 5 g | $1418.00 | |||
2-Keto-L-gulonic Acid, 10 g | sc-488772C | 10 g | $2346.00 |