2-Iodo Adenosine (CAS 35109-88-7)

2-Iodo adenosine, a derivative of adenosine modified with an iodine atom, has garnered significant attention in biochemical and pharmacological research due to its potential as a powerful tool in studying purinergic signaling pathways and nucleoside metabolism. This compound acts as a nucleoside analog and can be phosphorylated by adenosine kinase, leading to its incorporation into nucleic acids. Furthermore, 2-iodo adenosine exhibits affinity for adenosine receptors, particularly A1 and A3 subtypes, affecting downstream signaling cascades mediated by these receptors. In cellular studies, it has been utilized to investigate the physiological roles of adenosine receptors in various biological processes, such as neurotransmission, immune modulation, and cardiovascular regulation. Additionally, 2-iodo adenosine serves as a substrate for enzymes involved in purine salvage pathways, contributing to the understanding of nucleoside metabolism and its dysregulation in pathological conditions. Moreover, researchers have explored its potential as a radioisotope-labeled tracer for positron emission tomography (PET) imaging studies, facilitating the non-invasive visualization and quantification of adenosine receptor distribution and function in living organisms. Overall, 2-iodo adenosine holds promise as a versatile research tool for elucidating purinergic signaling mechanisms, studying nucleoside metabolism, and advancing imaging techniques in biomedical research.