2-Hydroxyphenylacetic Acid (CAS 614-75-5)
QUICK LINKS
2-Hydroxyphenylacetic Acid is an intermediate in the synthesis of atenolol and 3,4-dihydroxyphenylacetic acid. 2-Hydroxyphenylacetic acid (2-HPAA) is present in the human body and various food sources as a phenolic acid. It plays a role as an intermediate in the metabolic pathways of phenylalanine, tyrosine, and other aromatic amino acids. Additionally, it contributes to the synthesis pathway of catecholamines, including adrenaline and noradrenaline, which are vital hormones. Moreover, 2-Hydroxyphenylacetic acid serves as a significant intermediate in the production of dopamine, serotonin, and melatonin. The function of 2-Hydroxyphenylacetic acid extends to inhibiting the enzymes tyrosine hydroxylase and phenylalanine hydroxylase. The former is responsible for the synthesis of catecholamines, while the latter plays a role in the metabolism of phenylalanine.
2-Hydroxyphenylacetic Acid (CAS 614-75-5) References
- Synthesis of hydroxytyrosol, 2-hydroxyphenylacetic acid, and 3-hydroxyphenylacetic acid by differential conversion of tyrosol isomers using Serratia marcescens strain. | Allouche, N. and Sayadi, S. 2005. J Agric Food Chem. 53: 6525-30. PMID: 16076144
- Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. | Manna, SK., et al. 2010. J Proteome Res. 9: 4176-88. PMID: 20540569
- Biotransformation of phenylacetonitrile to 2-hydroxyphenylacetic acid by marine fungi. | de Oliveira, JR., et al. 2013. Mar Biotechnol (NY). 15: 97-103. PMID: 22790719
- Tyrosol and its analogues inhibit alpha-melanocyte-stimulating hormone induced melanogenesis. | Wen, KC., et al. 2013. Int J Mol Sci. 14: 23420-40. PMID: 24287915
- Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation. | Wu, C., et al. 2015. Sci Rep. 5: 10868. PMID: 26040782
- The study of biological activity of transformation products of diclofenac and its interaction with chlorogenic acid. | Matejczyk, M., et al. 2020. J Environ Sci (China). 91: 128-141. PMID: 32172961
- Identification of a self-sufficient cytochrome P450 monooxygenase from Cupriavidus pinatubonensis JMP134 involved in 2-hydroxyphenylacetic acid catabolism, via homogentisate pathway. | Donoso, RA., et al. 2021. Microb Biotechnol. 14: 1944-1960. PMID: 34156761
- Urinary Spermidine Predicts and Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery. | Martin-Lorenzo, M., et al. 2021. Antioxidants (Basel). 10: PMID: 34199603
- Spectroscopic, Thermal, Microbiological, and Antioxidant Study of Alkali Metal 2-Hydroxyphenylacetates. | Samsonowicz, M., et al. 2021. Materials (Basel). 14: PMID: 34947419
- Alteration of Serum Metabolites in Women of Reproductive Age with Chronic Constipation. | Liu, S., et al. 2022. Med Sci Monit. 28: e934117. PMID: 35236817
- Serum metabolome alterations in patients with early nonalcoholic fatty liver disease. | Wang, X., et al. 2022. Biosci Rep. 42: PMID: 36124945
- Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis. | Kolaříková, V., et al. 2022. Int J Mol Sci. 23: PMID: 36499496
- Determination of 2-hydroxyphenylacetic acid (2HPAA) in urine after oral and parenteral administration of coumarin by gas-liquid chromatography with flame-ionization detection. | Meineke, I., et al. 1998. J Pharm Biomed Anal. 17: 487-92. PMID: 9656160
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Hydroxyphenylacetic Acid, 50 g | sc-220741 | 50 g | $240.00 |