Molecular structure of 2-hydroxy Estradiol, CAS Number: 362-05-0
2-hydroxy Estradiol (CAS 362-05-0)
Alternate Names:
1,3,5(10)-Estratriene-2,3-17β-triol; Estra-1,3,5(10)-triene-2,3,17-triol
Application:
2-hydroxy Estradiol is a compound with potential value in cancer research
CAS Number:
362-05-0
Purity:
≥95%
Molecular Weight:
288.38
Molecular Formula:
C18H24O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Hydroxy Estradiol is a metabolite of estradiol, arising from the enzymatic hydroxylation of estradiol at the 2-position of the aromatic A-ring. Estradiol is an estrogen, a steroid hormone that plays roles in the regulation of reproductive and secondary sexual characteristics, as well as various metabolic processes. The formation of 2-Hydroxy Estradiol is part of the metabolic pathway of estradiol, which is primarily mediated by cytochrome P450 enzymes. 2-Hydroxy Estradiol is considered to be a less potent estrogen than estradiol, but it retains some affinity for estrogen receptors, allowing it to participate in estrogenic signaling to a certain extent. 2-Hydroxy Estradiol is rapidly metabolized by catechol-O-methyltransferase (COMT) to 2-methoxy estradiol.
2-hydroxy Estradiol (CAS 362-05-0) References
- 2-OH-estradiol, an endogenous hormone with neuroprotective functions. | Teepker, M., et al. 2003. J Psychiatr Res. 37: 517-23. PMID: 14563383
- New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. | Mooberry, SL. 2003. Curr Opin Oncol. 15: 425-30. PMID: 14624224
- Mechanism of action of 2-methoxyestradiol: new developments. | Mooberry, SL. 2003. Drug Resist Updat. 6: 355-61. PMID: 14744499
- 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. | Zacharia, LC., et al. 2004. J Pharmacol Exp Ther. 309: 1093-7. PMID: 14872091
- 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells. | Gao, N., et al. 2004. Toxicol Appl Pharmacol. 196: 124-35. PMID: 15050414
- Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. | Dubey, RK., et al. 2004. J Clin Endocrinol Metab. 89: 3922-31. PMID: 15292328
- Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites. | Fernandez, SV., et al. 2005. Int J Oncol. 26: 691-5. PMID: 15703825
- In vitro short-term test evaluation of catecholestrogens genotoxicity. | Rossi, D., et al. 2007. J Steroid Biochem Mol Biol. 105: 98-105. PMID: 17590328
- 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. | Becker, CM., et al. 2008. Am J Pathol. 172: 534-44. PMID: 18202195
- Evaluation of treatment for dry eye with 2-hydroxyestradiol using a dry eye rat model. | Higuchi, A., et al. 2016. Mol Vis. 22: 446-53. PMID: 27186071
- Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor: Short title: Kynurenine action on human decidualization. | Wang, PC., et al. 2020. Reprod Toxicol. 96: 282-292. PMID: 32781018
- Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-hydroxy estrone and 2-hydroxy estradiol. | Nakano, M., et al. 1987. Biochem Biophys Res Commun. 142: 919-24. PMID: 3827906
- Anovulation in female rats induced by neonatal administration of the catechol estrogens, 2-hydroxy-estradiol and 4-hydroxy-estradiol. | MacLusky, NJ., et al. 1983. Neuroendocrinology. 37: 321-7. PMID: 6196675
- Estrogen 2-, 4-, 6- or 16-hydroxylation by human follicles shown by gas chromatography-mass spectrometry associated with stable isotope dilution. | Dehennin, L., et al. 1984. J Steroid Biochem. 20: 465-71. PMID: 6708529
- Interaction of estradiol and 2-hydroxy-estradiol with histamine receptors at hypothalamic level. | Portaleone, P., et al. 1980. Brain Res. 187: 216-20. PMID: 7357469
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-hydroxy Estradiol, 1 mg | sc-205085 | 1 mg | $94.00 | |||
2-hydroxy Estradiol, 1 mg | sc-205085-CW | 1 mg | $129.00 | |||
2-hydroxy Estradiol, 5 mg | sc-205085A | 5 mg | $346.00 | |||
2-hydroxy Estradiol, 10 mg | sc-205085B | 10 mg | $586.00 | |||
2-hydroxy Estradiol, 25 mg | sc-205085C | 25 mg | $1166.00 |