2-hydroxy Estradiol CAS: 362-05-0
MF: C18H24O3
MW: 288.38
A compound with potential value in cancer research.

2-hydroxy Estradiol (CAS 362-05-0)

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Synonym: 1,3,5(10)-Estratriene-2,3-17β-triol; Estra-1,3,5(10)-triene-2,3,17-triol
Application: A compound with potential value in cancer research
CAS Number: 362-05-0
Purity: ≥95%
Molecular Weight: 288.38
Molecular Formula: C18H24O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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2-hydroxy Estradiol (2-HE) is rapidly metabolized by catechol-O-methyltransferase (COMT) to 2-methoxy estradiol (2-ME2) with a half-life of approximately ten minutes in rats. 2-ME2 has garnered considerable attention as an anticancer agent due to its apparent inhibition of angiogenesis. Due to the rapid metabolism of 2-HE2, the effects attributed to 2-HE2, may actually be those of 2-ME2.


References

1. Mooberry, Susan L., et al., 2003. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Current opinion in oncology. 15(6): 425-30. PMID: 14624224
2. Mooberry, Susan L., et al., 2003. Mechanism of action of 2-methoxyestradiol: new developments. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 6(6): 355-61. PMID: 14744499
3. Zacharia, Lefteris C., et al., 2004. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. The Journal of pharmacology and experimental therapeutics. 309(3): 1093-7. PMID: 14872091
4. Becker, Christian M., et al., 2008. 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. The American journal of pathology. 172(2): 534-44. PMID: 18202195

Physical State :
Solid
Storage :
Store at -20° C
Boiling Point :
430.31° C (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
247304

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Certificate of Analysis

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