2-hydroxy Estradiol CAS: 362-05-0
MF: C18H24O3
MW: 288.38
A compound with potential value in cancer research.

2-hydroxy Estradiol (CAS 362-05-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 138ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 1,3,5(10)-Estratriene-2,3-17β-triol; Estra-1,3,5(10)-triene-2,3,17-triol
Application: A compound with potential value in cancer research
CAS Number: 362-05-0
Purity: ≥95%
Molecular Weight: 288.38
Molecular Formula: C18H24O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

2-hydroxy Estradiol (2-HE) is rapidly metabolized by catechol-O-methyltransferase (COMT) to 2-methoxy estradiol (2-ME2) with a half-life of approximately ten minutes in rats. 2-ME2 has garnered considerable attention as an anticancer agent due to its apparent inhibition of angiogenesis. Due to the rapid metabolism of 2-HE2, the effects attributed to 2-HE2, may actually be those of 2-ME2.


1. Mooberry, Susan L., et al., 2003. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Current opinion in oncology. 15(6): 425-30. PMID: 14624224
2. Mooberry, Susan L., et al., 2003. Mechanism of action of 2-methoxyestradiol: new developments. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 6(6): 355-61. PMID: 14744499
3. Zacharia, Lefteris C., et al., 2004. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. The Journal of pharmacology and experimental therapeutics. 309(3): 1093-7. PMID: 14872091
4. Becker, Christian M., et al., 2008. 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. The American journal of pathology. 172(2): 534-44. PMID: 18202195

Physical State :
Storage :
Store at -20° C
Boiling Point :
430.31° C (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 134ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.