Date published: 2025-9-26

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2-Aminopyrazine (CAS 5049-61-6)

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Alternate Names:
pyrazinamine
Application:
2-Aminopyrazine is a synthetic intermediate
CAS Number:
5049-61-6
Molecular Weight:
95.10
Molecular Formula:
C4H5N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Aminopyrazine is a compound that functions as a building block in the synthesis of various organic compounds. It serves as a key intermediate in the production of agrochemicals, and other fine chemicals. Its mechanism of action involves participating in nucleophilic aromatic substitution reactions, allowing for the introduction of functional groups at specific positions on the pyrazine ring. This enables the modification of structure to create new compounds with diverse properties and applications. 2-Aminopyrazine can act as a ligand in coordination chemistry, forming complexes with transition metal ions and facilitating the development of novel catalysts and materials. Its ability to undergo various chemical transformations may be a versatile for the exploration of new routes and the discovery of innovative compounds with potential industrial and applications.


2-Aminopyrazine (CAS 5049-61-6) References

  1. Mercapturic acid formation from 2-aminopyrazine in rats.  |  Lunn, WH. and Shadle, JK. 1992. Xenobiotica. 22: 1239-41. PMID: 1492416
  2. Antibacterial cobalt(II) and zinc(II) complexes of pyrazine-derived NNO and NNN donor Schiff-bases.  |  Chohan, ZH. and Mushtaq, S. 2000. Pak J Pharm Sci. 13: 21-7. PMID: 16414835
  3. Copper(I) cyanide networks: synthesis, luminescence behavior and thermal analysis. Part 1. Diimine ligands.  |  Tronic, TA., et al. 2007. Inorg Chem. 46: 8897-912. PMID: 17850140
  4. Synthesis of some new anils: part 1. Reaction of 2-hydroxy-benzaldehyde and 2-hydroxynaphthaldehyde with 2-aminopyridene and 2-aminopyrazine.  |  Asiri, AM. and Badahdah, KO. 2007. Molecules. 12: 1796-804. PMID: 17960088
  5. Poly[bis(mu2-2-aminopyrazine-kappa2N1:N4)(mu2-nitrato-kappa2O:O)(nitrato-kappa2O,O')disilver(I)]: an achiral two-dimensional coordination polymer forming chiral crystals.  |  Sun, D., et al. 2009. Acta Crystallogr C. 65: m478-80. PMID: 19966432
  6. Multistimuli Response Micro- and Nanolayers of a Coordination Polymer Based on Cu2 I2 Chains Linked by 2-Aminopyrazine.  |  Conesa-Egea, J., et al. 2017. Small. 13: PMID: 28692791
  7. Coordination Polymers Based on Phthalic Acid and Aminopyrazine Ligands: On the Importance of N⁻H···π Interactions.  |  Hossain, A., et al. 2018. Polymers (Basel). 10: PMID: 30966218
  8. Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor.  |  Knegtel, R., et al. 2019. J Med Chem. 62: 5547-5561. PMID: 31074988
  9. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites.  |  Niemand, J., et al. 2021. ACS Infect Dis. 7: 2904-2916. PMID: 34569223
  10. Experimental and computational tuning of metalla-N-heterocyclic carbenes at palladium(II) and platinum(II) centers.  |  Kashina, MV., et al. 2022. Dalton Trans. 51: 6718-6734. PMID: 35415731
  11. An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19.  |  Karatas, H., et al. 2023. Chem Zvesti. 77: 1695-1702. PMID: 36466109

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Aminopyrazine, 5 g

sc-205081
5 g
$49.00

2-Aminopyrazine, 25 g

sc-205081A
25 g
$122.00