Molecular structure of 2-Amino-1-phenylethanol, CAS Number: 7568-93-6
2-Amino-1-phenylethanol (CAS 7568-93-6)
Alternate Names:
α-(Aminomethyl)benzyl alcohol, DL-β-Hydroxyphenethylamine, Phenylethanolamine
Application:
2-Amino-1-phenylethanol is a β-hydroxylated phenethylamine
CAS Number:
7568-93-6
Molecular Weight:
137.18
Molecular Formula:
C8H11NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2-Amino-1-phenylethanol (2-APE) is a beta-hydroxylated phenethylamine. It has been studied as a substrate for phenylethanolamine N-methyl transferase. It acts as an agonist at a number of neurotransmitter receptors, including serotonin, dopamine, and norepinephrine receptors. 2-Amino-1-phenylethanol is also an inhibitor of cyclooxygenase and lipoxygenase enzymes, which are involved in the regulation of inflammation and immune responses. Additionally, it has been found to modulate gene expression, cell proliferation, and cell signaling pathways.
2-Amino-1-phenylethanol (CAS 7568-93-6) References
- Highly enantioselective ruthenium-catalyzed reduction of ketones employing readily available Peptide ligands. | Bøgevig, A., et al. 2004. Chemistry. 10: 294-302. PMID: 14695575
- Polymer-coated hollow fiber microextraction combined with on-column stacking in capillary electrophoresis. | Basheer, C., et al. 2006. J Chromatogr A. 1128: 267-72. PMID: 16824535
- The effect of solvation on biomolecular conformation: 2-amino-1-phenylethanol. | Baker, CM. and Grant, GH. 2007. J Phys Chem B. 111: 9940-54. PMID: 17672488
- Solvent control of optical resolution of 2-amino-1-phenylethanol using dehydroabietic acid. | Taniguchi, K., et al. 2008. Org Biomol Chem. 6: 458-63. PMID: 18219414
- Shape of biomolecules by free jet microwave spectroscopy: 2-amino-1-phenylethanol and 2-methylamino-1-phenylethanol. | Melandri, S., et al. 2009. J Phys Chem A. 113: 7769-73. PMID: 19505067
- Comparison of chiral electrophoretic separation methods for phenethylamines and application on impurity analysis. | Borst, C. and Holzgrabe, U. 2010. J Pharm Biomed Anal. 53: 1201-9. PMID: 20638811
- Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives. | Chaparro, MJ., et al. 2014. ACS Med Chem Lett. 5: 657-61. PMID: 24944739
- Direct Catalytic Synthesis of Unprotected 2-Amino-1-Phenylethanols from Alkenes by Using Iron(II) Phthalocyanine. | Legnani, L. and Morandi, B. 2016. Angew Chem Int Ed Engl. 55: 2248-51. PMID: 26836348
- Rotational Spectrum and Conformational Analysis of N-Methyl-2-Aminoethanol: Insights into the Shape of Adrenergic Neurotransmitters. | Calabrese, C., et al. 2018. Front Chem. 6: 25. PMID: 29520356
- Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives. | Woo, AY., et al. 2019. Acta Pharmacol Sin. 40: 1095-1105. PMID: 30643208
- Asymmetric N-H Insertion Reaction with Chiral Aminoalcohol as Catalytic Core of Cinchona Alkaloids. | Shinohara, H., et al. 2019. Chem Pharm Bull (Tokyo). 67: 393-396. PMID: 30930443
- Nitrogen-Doped Mixed-Phase Cobalt Nanocatalyst Derived from a Trinuclear Mixed-Valence Cobalt(III)/Cobalt(II) Complex for High-Performance Oxygen Evolution Reaction. | Ghosh, T., et al. 2021. Inorg Chem. 60: 2333-2346. PMID: 33502850
- Enantioselective Recognition of Racemic Amino Alcohols in Aqueous Solution by Chiral Metal-Oxide Keplerate {Mo132 } Cluster Capsules. | Pow, RW., et al. 2021. Chemistry. 27: 12327-12334. PMID: 34196438
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Amino-1-phenylethanol, 10 g | sc-254126 | 10 g | $88.00 |