![2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester (CAS 1159576-98-3) - chemical structure](https://media.scbt.com/product/2--3-chlorophenyl-methyl-5-hydroxy-1h-benzgindole-3-carboxylic-acid-ethyl-ester-1159576-98-3-structure_20_91_b_209136.jpg)
![2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester (CAS 1159576-98-3) - chemical structure](https://media.scbt.com/product/2--3-chlorophenyl-methyl-5-hydroxy-1h-benzgindole-3-carboxylic-acid-ethyl-ester-1159576-98-3-structure_20_91_t_209136.jpg "Molecular structure of 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester, CAS Number: 1159576-98-3")
Molecular structure of 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester, CAS Number: 1159576-98-3
2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester (CAS 1159576-98-3)
CAS Number:
1159576-98-3
Molecular Weight:
379.8
Molecular Formula:
C22H18ClNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. A potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.
2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester (CAS 1159576-98-3) References
- Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. | Karg, EM., et al. 2009. J Med Chem. 52: 3474-83. PMID: 19492852
- A fluorescence-based assay for measuring the redox potential of 5-lipoxygenase inhibitors. | Lee, S., et al. 2014. PLoS One. 9: e87708. PMID: 24498359
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester, 1 mg | sc-287639 | 1 mg | $56.00 | |||
2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester, 5 mg | sc-287639A | 5 mg | $251.00 |