Date published: 2026-1-15

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19(20)-EpDPE

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Molecular Weight:
344.5
Molecular Formula:
C22H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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19(20)-EpDPE, assigned CAS number 183012-99-9, is an epoxy derivative of docosapentaenoic acid (DPA), an omega-3 fatty acid less commonly discussed than its relatives EPA and DHA but equally significant in certain biological contexts. This compound is synthesized through the action of cytochrome P450 enzymes, which introduce an epoxide group into the DPA molecule specifically between the 19th and 20th carbon atoms. In biochemical research, 19(20)-EpDPE has been used to investigate its influence on cellular mechanisms, particularly in the context of signaling pathways that govern cellular responses to environmental stimuli. This compound interacts with various receptors and enzymes within cells, potentially affecting processes such as the regulation of ion channels, modulation of inflammatory mediators, and alterations in gene expression related to cell survival and function. Studies utilizing 19(20)-EpDPE focus on elucidating its role in maintaining cellular homeostasis and its involvement in signaling pathways that respond to oxidative stress and other cellular stresses. By understanding the actions of 19(20)-EpDPE, researchers aim to shed light on the broader implications of lipid-derived epoxides in cell signaling, offering insights into how cells adapt to and manage complex physiological challenges.


19(20)-EpDPE References

  1. Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism.  |  Spector, AA. and Kim, HY. 2015. Biochim Biophys Acta. 1851: 356-65. PMID: 25093613
  2. The role of AHR-inducible cytochrome P450s in metabolism of polyunsaturated fatty acids.  |  Hankinson, O. 2016. Drug Metab Rev. 48: 342-50. PMID: 27358009
  3. Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid.  |  Isobe, Y., et al. 2018. Sci Rep. 8: 7954. PMID: 29784972
  4. Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers.  |  Walker, RE., et al. 2021. Physiol Rep. 9: e14480. PMID: 33625776
  5. Cytochrome P450 epoxygenase-derived EPA and DHA oxylipins 17,18-epoxyeicosatetraenoic acid and 19,20-epoxydocosapentaenoic acid promote BAT thermogenesis and WAT browning through the GPR120-AMPKα signaling pathway.  |  Yang, X., et al. 2022. Food Funct. 13: 1232-1245. PMID: 35019933
  6. Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis.  |  Yoshida, M., et al. 2022. FASEB J. 36: e22648. PMID: 36374250
  7. Enzymatically-epoxidized docosahexaenoic acid, 19,20-EpDPE, suppresses hepatic crown-like structure formation and nonalcoholic steatohepatitis fibrosis through GPR120.  |  Aoki, H., et al. 2023. Biochim Biophys Acta Mol Cell Biol Lipids. 1868: 159275. PMID: 36566874
  8. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate.  |  Yamane, M., et al. 1994. J Chromatogr. 652: 123-36. PMID: 8006098

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

19(20)-EpDPE, 25 µg

sc-220658
25 µg
$43.00

19(20)-EpDPE, 50 µg

sc-220658A
50 µg
$83.00