13-cis-Retinol (CAS 2052-63-3)
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13-cis-Retinol is a derivative of vitamin A that plays a pivotal role in the field of dermatological research, particularly in understanding the pathophysiology of acne and the regulation of sebaceous gland activity. Its mechanism of action is multifaceted, primarily involving the normalization of DNA transcription in cells. This compound has been instrumental in elucidating the complex interactions between vitamin A derivatives and skin cell proliferation and differentiation. Moreover, 13-cis-Retinol serves as a critical tool in genetic and molecular biology research, offering insights into the retinoid signaling pathways that govern embryonic development and cell growth regulation. It also plays a role in the development and maintenance of the immune system and is involved in the metabolism of fats and carbohydrates. In addition, 13-cis-Retinol is important for vision and is involved in the formation of the photoreceptor cells in the retina.
13-cis-Retinol (CAS 2052-63-3) References
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- Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. | Sieving, PA., et al. 2001. Proc Natl Acad Sci U S A. 98: 1835-40. PMID: 11172037
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- Cellular metabolism and actions of 13-cis-retinoic acid. | Blaner, WS. 2001. J Am Acad Dermatol. 45: S129-35. PMID: 11606944
- 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? | Karlsson, T., et al. 2003. Biochem Biophys Res Commun. 303: 273-8. PMID: 12646198
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13-cis-Retinol, 1 mg | sc-476711 | 1 mg | $632.00 | |||
13-cis-Retinol, 10 mg | sc-476711A | 10 mg | $3728.00 | |||
13-cis-Retinol, 50 mg | sc-476711B | 50 mg | $6768.00 | |||
13-cis-Retinol, 100 mg | sc-476711C | 100 mg | $13015.00 |