Molecular structure of 13,14-dihydro-15-keto Prostaglandin E2-d4, CAS Number: 363-23-5 (unlabeled)
13,14-dihydro-15-keto Prostaglandin E2-d4 (CAS 363-23-5 (unlabeled))
Application:
13,14-dihydro-15-keto Prostaglandin E2-d4 is an isotopically labeled metabolite of PGE2 with longer half-life
CAS Number:
363-23-5 (unlabeled)
Molecular Weight:
356.5
Molecular Formula:
C20H28D4O5
Supplemental Information:
This product is subject to an additional Dangerous Goods shipping charge.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Contains four deuterium atoms at the 3, 3 · , 4, and 4 · positions. Intended for use as an internal standard for the quantification of 13,14-dh-15-keto PGE2 by GC- or LC-mass spectrometry (MS). 10-100 pg/ml.1,2 Undergoes further metabolism and chemical decomposition, giving it a relatively short half-life. In dogs, the plasma half-life of 13,14-dh-15-keto PGE2 is about 9 minutes.1 In humans the metabolite has a similar short half-life, making it a poor choice of analytes for assays designed to measure total PGE2 biosynthesis.3,4
13,14-dihydro-15-keto Prostaglandin E2-d4 (CAS 363-23-5 (unlabeled)) References
- On the metabolism of prostaglandins E 1 and E 2 in man. | Hamberg, M. and Samuelsson, B. 1971. J Biol Chem. 246: 6713-21. PMID: 5126221
- A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: an indirect index of their in vivo disposition and pharmacokinetics. | Bothwell, W., et al. 1982. J Pharmacol Exp Ther. 220: 229-35. PMID: 6948952
- The stability of 13,14-dihydro-15 keto-PGE2. | Fitzpatrick, FA., et al. 1980. Prostaglandins. 19: 917-31. PMID: 7384560
- Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. | Nishigaki, N., et al. 1996. Mol Pharmacol. 50: 1031-7. PMID: 8863851
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13,14-dihydro-15-keto Prostaglandin E2-d4, 25 µg | sc-220597 | 25 µg | $106.00 | |||
13,14-dihydro-15-keto Prostaglandin E2-d4, 50 µg | sc-220597A | 50 µg | $201.00 |