13,14-dihydro-15-keto Prostaglandin D2-d4
Alternate Names:
13,14-dihydro-15-keto PGD2-d4
Molecular Weight:
356.5
Molecular Formula:
C20H28D4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Contains four deuterium atoms at the 3, 3′, 4, and 4′ positions and is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 by GC- or LC-mass spectrometry. A metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. Recently identified as a selective agonist for the CRTH2/DP2 receptor.1 Also inhibits ion flux in a canine colonic mucosa preparation.2 In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.3,4
13,14-dihydro-15-keto Prostaglandin D2-d4 References
1 Rangachari, P.K., Betti, P. Biological activity of metabolites of PGD2 on canine proximal colon. Am J Physiol 264, G886-G894 (1993). 2 Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 193(2) 255-261 (2001). 3 Liston, T.E., Roberts, L.J. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J Biol Chem 260 13172-13180 (1985). 4 Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal Biochem 193 142-148 (1991).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13,14-dihydro-15-keto Prostaglandin D2-d4, 25 µg | sc-220595 | 25 µg | $127.00 | |||
13,14-dihydro-15-keto Prostaglandin D2-d4, 50 µg | sc-220595A | 50 µg | $241.00 |