12-oxo Leukotriene B₄ in acetonitrile (CAS 136696-10-1)

12-oxo Leukotriene B₄ is a leukotrienes. Leukotrienes comprise a family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes possess a conjugated triene structure which gives them their name. They are generally isolated from leukocytes and primarily act through specific G protein-coupled receptors. 12-oxo Leukotriene B₄ is derived from arachidonic acid via the 5-LO pathway. It has been shown to promote many leukocyte functions including stimulation of ion fluxes, aggregation, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. 12-oxo-LTB4 is about 70-fold less potent than LTB4 at stimulating Ca²⁺ mobilization in human neutrophils and has also been shown to be significantly less potent than LTB4 at stimulating neutrophil migration.