Molecular structure of 11α-Hydroxyprogesterone, CAS Number: 80-75-1
11α-Hydroxyprogesterone (CAS 80-75-1)
See product citations (2)
Alternate Names:
4-Pregnen-11α-ol-3,20-dione; 11α-Hydroxypregn-4-ene-3,20-dione
CAS Number:
80-75-1
Molecular Weight:
330.46
Molecular Formula:
C21H30O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
11α-Hydroxyprogesterone is a steroid hormone and a derivative of progesterone, a natural hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. The compound is characterized by the addition of a hydroxyl group at the 11-alpha position on the progesterone molecule. This structural modification alters the hormone′s biological activity and solubility. The presence of the hydroxyl group at the 11-alpha position impacts the hormone′s interaction with its receptors and its metabolic pathways, potentially changing its physiological effects. 11α-Hydroxyprogesterone is of interest in endocrine research where it may be studied for its roles in various biological processes including its influence on cortisol synthesis pathways and its potential effects on anti-inflammatory and immune-modulating activities.
11α-Hydroxyprogesterone (CAS 80-75-1) References
- 11beta-hydroxysteroid dehydrogenase functions reversibly as an oxidoreductase in the rat hippocampus in vivo. | Jellinck, PH., et al. 1999. J Steroid Biochem Mol Biol. 71: 139-44. PMID: 10659702
- Identification of monohydroxy progesterones produced by CYP106A2 using comparative HPLC and electrospray ionisation collision-induced dissociation mass spectrometry. | Lisurek, M., et al. 2004. Biochem Biophys Res Commun. 319: 677-82. PMID: 15178459
- Glucuronidation of steroidal alcohols using iodosugar and imidate donors. | Harding, JR., et al. 2005. Org Biomol Chem. 3: 1501-7. PMID: 15827648
- Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivation. | Lewis, BC., et al. 2007. Biochem Pharmacol. 73: 1463-73. PMID: 17223084
- Steroid extraction in a microchannel system--mathematical modelling and experiments. | Znidarsic-Plazl, P. and Plazl, I. 2007. Lab Chip. 7: 883-9. PMID: 17594008
- Biotransformation of some steroids by Aspergillus wentii. | Yildirim, K., et al. 2010. Z Naturforsch C J Biosci. 65: 688-92. PMID: 21319711
- Changing the regioselectivity of a P450 from C15 to C11 hydroxylation of progesterone. | Nguyen, KT., et al. 2012. Chembiochem. 13: 1161-6. PMID: 22532270
- Detection of urine metabolites in polycystic ovary syndrome by UPLC triple-TOF-MS. | Wang, W., et al. 2015. Clin Chim Acta. 448: 39-47. PMID: 26093338
- Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases. | Hull, CM., et al. 2017. Biotechnol Biofuels. 10: 226. PMID: 29021826
- An efficient biotransformation of progesterone into 11α-hydroxyprogesterone by Rhizopus microsporus var. oligosporus. | Nickavar, B., et al. 2018. Z Naturforsch C J Biosci. 74: 9-15. PMID: 30367812
- 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro. | Gent, R., et al. 2019. J Steroid Biochem Mol Biol. 191: 105369. PMID: 31039398
- Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic Strain Isaria farinosa KCh KW1.1. | Kozłowska, E., et al. 2022. Int J Mol Sci. 23: PMID: 35806021
- Ultra-performance convergence chromatography tandem mass spectrometry analysis of adrenal and gonadal steroid hormones in southern white rhinoceros(Ceratotherium simum simum) faeces and serum. | Gent, R., et al. 2023. J Chromatogr B Analyt Technol Biomed Life Sci. 1215: 123576. PMID: 36529070
- Expression of the Fab enzymes (Fab I and Fab Z) from Plasmodium falciparum after exposure to Artemisia afra plant extracts and drugs screening. | Kane, NF., et al. 2023. J Parasit Dis. 47: 46-58. PMID: 36910309
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
11α-Hydroxyprogesterone, 1 g | sc-287291 | 1 g | $210.00 | |||
11α-Hydroxyprogesterone, 5 g | sc-287291A | 5 g | $920.00 | |||
11α-Hydroxyprogesterone, 50 g | sc-287291B | 50 g | $5100.00 |