Date published: 2026-2-13

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1,3,5-Trifluorobenzene (CAS 372-38-3)

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Alternate Names:
sym-Trifluorobenzene
Application:
1,3,5-Trifluorobenzene is Used in the synthesis of (−)-epicatechin and its 3-O-gallate
CAS Number:
372-38-3
Molecular Weight:
132.08
Molecular Formula:
C6H3F3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,3,5-Trifluorobenzene (TFB), known by its chemical formula C6H3F3, is an organic compound that exists as a colorless liquid emitting a pleasant fruity fragrance. Its versatility as an intermediate in organic synthesis makes it a valuable component in the production of a broad range of products, including fragrances, pesticides, herbicides, plastics, and dyes. Researchers utilize 1,3,5-Trifluorobenzene in diverse scientific research endeavors. Its involvement spans studies on enzyme-catalyzed reactions and the synthesis of innovative compounds. Furthermore, it plays a role in the exploration of molecular recognition and the development of molecular recognition principles. Due to its possession of three fluorine atoms, 1,3,5-Trifluorobenzene exhibits high reactivity. It readily engages in reactions with various compounds, including amines, alcohols, and carboxylic acids. When reacting with amines, it forms amides, while its reaction with alcohols results in the formation of trifluoroacetate esters. Carboxylic acid reactions yield trifluoroacetate anions. Particularly notable is its reaction with amines enabling the formation of amide bonds between chemicals and their target proteins.


1,3,5-Trifluorobenzene (CAS 372-38-3) References

  1. Temperature-dependent optical Kerr effect spectroscopy of aromatic liquids.  |  Loughnane, BJ., et al. 2006. J Phys Chem B. 110: 5708-20. PMID: 16539516
  2. Van der Waals complexes of small molecules with benzenoid rings: influence of multipole moments on their mutual orientation.  |  Mishra, BK. and Sathyamurthy, N. 2007. J Phys Chem A. 111: 2139-47. PMID: 17388262
  3. Additivity of ring distortions in halogen-substituted aromatics: a gas-phase electron diffraction and computational study.  |  Wann, DA., et al. 2007. J Phys Chem A. 111: 7882-7. PMID: 17658773
  4. The Jahn-Teller and pseudo-Jahn-Teller effects in the low-lying electronic states of 1,3,5-trifluorobenzene radical cation.  |  Mondal, T. and Mahapatra, S. 2009. Phys Chem Chem Phys. 11: 10867-80. PMID: 19924321
  5. Selective aromatic C-F and C-H bond activation with silylenes of different coordinate silicon.  |  Jana, A., et al. 2010. J Am Chem Soc. 132: 10164-70. PMID: 20608652
  6. The role of the ethynyl substituent on the π-π stacking affinity of benzene: a theoretical study.  |  Lucas, X., et al. 2011. Chemphyschem. 12: 283-8. PMID: 21275020
  7. Computational study on C-H..π interactions of acetylene with benzene, 1,3,5-trifluorobenzene and coronene.  |  Dinadayalane, TC., et al. 2013. J Mol Model. 19: 2855-64. PMID: 23247410
  8. Total Syntheses of Perenniporides.  |  Morita, M., et al. 2015. Org Lett. 17: 5634-7. PMID: 26555442
  9. Total Synthesis of (+)-Vicenin-2.  |  Ho, TC., et al. 2016. Org Lett. 18: 4488-90. PMID: 27569251
  10. Desorption of Benzene, 1,3,5-Trifluorobenzene, and Hexafluorobenzene from a Graphene Surface: The Effect of Lateral Interactions on the Desorption Kinetics.  |  Smith, RS. and Kay, BD. 2018. J Phys Chem Lett. 9: 2632-2638. PMID: 29724099
  11. Progressive Hydrophobicity of Fluorobenzenes.  |  Kumar, A., et al. 2019. J Phys Chem B. 123: 10083-10088. PMID: 31661279
  12. Pyrolysis characteristics of cathode from spent lithium-ion batteries using advanced TG-FTIR-GC/MS analysis.  |  Yu, S., et al. 2020. Environ Sci Pollut Res Int. 27: 40205-40209. PMID: 32661975
  13. Lithium-mediated Ferration of Fluoroarenes.  |  Maddock, LCH., et al. 2020. Chimia (Aarau). 74: 866-870. PMID: 33243321

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,3,5-Trifluorobenzene, 5 g

sc-223002
5 g
$102.00

1,3,5-Trifluorobenzene, 25 g

sc-223002A
25 g
$367.00