1,2-O-O-Dihexadecyl-rac-glycero-3-phosphoethanolamine sodium salt

1,2-O-O-Dihexadecyl-rac-glycero-3-phosphoethanolamine sodium salt, known as DHPE-Na, is a synthetic phospholipid used primarily in the study of lipid bilayers and membrane dynamics within the realm of biophysical research. This molecule consists of a glycerol backbone to which two hexadecyl chains are attached at the sn-1 and sn-2 positions, fostering the creation of stable, less fluid lipid bilayers that mimic certain characteristics of natural cellular membranes. The sn-3 position is linked to a phosphoethanolamine group, providing a negatively charged headgroup balanced by a sodium ion, which enhances the bilayer′s ability to simulate real biological membranes. DHPE-Na is instrumental in research focused on lipid bilayer assembly, the behavior of membranes under various physical conditions, and their interaction with proteins and other biomolecules. It is particularly valued for its role in forming vesicles and liposomes, crucial for understanding mechanisms such as vesicle trafficking and fusion. Additionally, DHPE-Na is applied in creating model systems for studying the biophysical properties of membranes, offering insights into the fundamental roles of lipids in cellular processes, all while steering clear of any direct pharmaceutical or therapeutic applications.