1,2-Dimethoxyethane (CAS 110-71-4)

1,2-Dimethoxyethane, commonly known as glyme or ethylene glycol dimethyl ether (EGDME), is a glycol ether and an organic compound featuring two methoxy groups attached to an ethylene group. This chemical is a colorless, hygroscopic liquid with a mild, ether-like odor, and it is known for its excellent solvent properties due to its ability to dissolve both polar and nonpolar compounds, making it extremely versatile. In research, 1,2-Dimethoxyethane is particularly valued in the field of electrochemistry, where it is frequently used as a high-permittivity solvent in the preparation of electrolyte solutions for batteries, especially lithium batteries. Its ability to solvate lithium salts effectively while maintaining good electrochemical stability under operating conditions makes it indispensable in studying and developing advanced battery technologies. Beyond battery research, 1,2-Dimethoxyethane is used in organic synthesis as a coordinating solvent, facilitating reactions such as Grignard reactions, where it stabilizes the Grignard reagent and allows for effective reaction with electrophiles. Additionally, its solvent characteristics are exploited in nuclear magnetic resonance (NMR) spectroscopy as a medium for analyzing less soluble compounds. The compound′s dual solvency and low toxicity also make it a preferred solvent in applications requiring a delicate balance of solvency power and gentle handling of sensitive materials, such as in the synthesis of pharmaceutical intermediates and specialty polymers.