(+)-U-50488 hydrochloride CAS: 67198-17-8
MF: C19H26Cl2N2O•HCl
MW: 405.79
An enantiomer of (±)-U-50488.

(+)-U-50488 hydrochloride (CAS 67198-17-8)

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Alternate Names: trans-(+)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide hydrochloride
Application (+)-U-50488 hydrochloride is an enantiomer of (±)-U-50488
CAS 등록번호: 67198-17-8
순도: ≥98%
분자량: 405.79
분자식: C19H26Cl2N2O•HCl
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

(+)-U-50488 hydrochloride is a less active enantiomer of (±)-U-50488. This compound is an agonist of the KOR (κ-opioid rececptor).


References

1. De Costa, B., et al. 1987. FEBS Lett. 223: 335-339.

Physical State :
Solid
용해도 :
Soluble in water (100 mM), and DMSO (100 mM).
저장 :
Store at room temperature
녹는점 :
73-74° C
비등점 :
496.6° C at 760 mmHg (Predicted)
굴절률 :
n20D 1.59 (Predicted)
Optical Activity :
α22/D 34.89°, c = 0.43 in methanol
IC50 :
Kappa opioid receptor: IC50 = 0.30 nM (Cavia porcellus); KOR-1: IC50 = 0.55 nM (human); Mu opioid receptor: IC50 = 1 nM (rat); Kappa opioid receptor: IC50 = 2.35 nM (mouse); Plasmodium falciparum: IC50 = 2.51 µM
Ki 데이타 :
KOR-1: Ki= 0.2 nM (human); Kappa opioid receptor: Ki= 0.31 nM (Cavia porcellus); Mu opioid receptor: Ki= 220 nM (Cavia porcellus); MOR-1: Ki= 290 nM (human)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00210224
SMILES :
CN([[email protected]@H]1CCCC[[email protected]]1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl

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분석증명서

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