TrkB Antibody (G-11): sc-136991

TrkB Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to detect TrkB, also known as NTRK2, in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TrkB monoclonal antibody (G-11) targets an epitope encompassing amino acids 209-298 of the human TrkB protein, ensuring precise binding to this critical region. TrkB is a member of the tropomyosin receptor kinase family and functions as a vital tyrosine kinase receptor for neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). These interactions are essential for the development, maintenance, and function of the central and peripheral nervous systems, influencing processes such as neuronal survival, differentiation, and synaptic plasticity. TrkB interacts with several key signaling proteins, including phospholipase C gamma (PLCγ), Shc adaptor proteins, and the phosphoinositide 3-kinase (PI3K) pathway, which collectively mediate downstream effects that regulate cellular responses to neurotrophic signals. Anti-TrkB antibody (G-11) enables researchers to explore these intricate protein interactions and their roles in neurodevelopmental and neurological disorders. Available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® variants, TrkB (G-11) antibody offers versatility for diverse experimental needs. TrkB monoclonal antibody (G-11) advances research into the molecular mechanisms of neuronal growth and function, as well as the development of therapeutic strategies targeting TrkB-mediated pathways in various neurological conditions.

The preferred p-Trk antibody is p-Trk Antibody (E-6): sc-8058.