TRAX Antibody (E-11): sc-271632

TRAX Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects TRAX in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRAX, also known as translin-associated factor X or TSNAX, is a crucial nuclear protein that plays a significant role in DNA repair and RNA processing by interacting with translin, a DNA-binding protein involved in chromosomal translocations. TRAX is predominantly expressed in the brain and testis, where TRAX contains an N-terminal bipartite nuclear localization signal (NLS) that facilitates transport into the nucleus, and a leucine zipper domain that is vital for protein-protein interactions. TRAX forms a complex with translin to engage with protein kinase activator C1D, thereby participating in the repair of DNA double-stranded breaks and the processing of dendritic RNA. Additionally, TRAX acts as a transcriptional regulator of GAP-43, a growth-associated protein that is essential for axonal regeneration and cell proliferation, highlighting TRAX′s importance in neural development and recovery processes. With versatile applications and critical biological functions, anti-TRAX antibody (E-11) serves as an invaluable tool for researchers studying cellular mechanisms related to DNA repair and neuronal growth.

The preferred TRAX antibody is TRAX Antibody (B-10): sc-271402.