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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 1 out of
Does not work even with overexpressionUsed it to visualize TMPRSS2 in transfected cells but got no signal even at 1:100 dilution. Customer service was great and sent an alternative product (H-4, sc-515727) free of charge, which worked well.
Date published: 2020-12-30
Rated 1 out of
Kein Signal in WBBei der Expression in Oozyten haben wir kein Signal in Ganzzelllysaten detektiert.