Tim9A Antibody (SA-19): sc-101285

Tim9A Antibody (SA-19) is a mouse monoclonal IgG2a kappa light chain antibody that detects Tim9A protein in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Tim9A antibody (SA-19) is available in non-conjugated format. Tim9A protein functions critically in mitochondrial processes, particularly importing nuclear-encoded precursor proteins into mitochondria, maintaining mitochondrial integrity and function. This process remains essential since mitochondria serve as cellular powerhouses, managing energy production and metabolic pathway regulation. Tim9A (SA-19) monoclonal antibody targets proteins located in mitochondrial intermembrane space, where Tim9A forms heteromeric complexes with Tim10 and Tim12 proteins, essential components of the translocation machinery facilitating protein movement across mitochondrial inner membranes. Tim9A protein defects have been associated with various neurodegenerative diseases, emphasizing Tim9A′s significance in cellular health and development. Tim9A maps to human chromosome 14q21 and shows expression in post-fracture calluses, suggesting involvement in tissue repair and regeneration.

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Tim9A Antibody (SA-19) References:

1. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins.  |  Jin, H., et al. 1999. Genomics. 61: 259-67. PMID: 10552927
2. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.  |  Bauer, MF., et al. 1999. FEBS Lett. 464: 41-7. PMID: 10611480
3. Import of proteins into mitochondria: a novel pathomechanism for progressive neurodegeneration.  |  Bauer, MF. and Neupert, W. 2001. J Inherit Metab Dis. 24: 166-80. PMID: 11405338
4. Cloning of a novel cDNA expressed during the early stages of fracture healing.  |  Hadjiargyrou, M., et al. 1998. Biochem Biophys Res Commun. 249: 879-84. PMID: 9731230
5. Tim9, a new component of the TIM22.54 translocase in mitochondria.  |  Adam, A., et al. 1999. EMBO J. 18: 313-9. PMID: 9889188
6. The preprotein translocase of the mitochondrial inner membrane: function and evolution.  |  Rassow, J., et al. 1999. J Mol Biol. 286: 105-20. PMID: 9931253

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tim9A Antibody (SA-19) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Tim9A Antibody (SA-19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tim9A Antibody (SA-19) Specifications

Alternate Product Name: Tim9A

Product Clone Name: SA-19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-90

Epitope Target: Tim9A

Epitope Species: human

Product Reactivity/Detection: Tim9A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Tim9A Antibody (SA-19): N/A