TBCE Antibody (D-11): sc-398209
- TBCE Antibody (D-11) is a mouse monoclonal IgG1 TBCE antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 422-451 within an internal region of TBCE of human origin
- TBCE Antibody (D-11) is recommended for detection of TBCE of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TBCE Antibody (D-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TBCE Antibody (D-11). This work is in progress.
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TBCE Antibody (D-11) is a mouse monoclonal IgG1 antibody that detects TBCE protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBCE (D-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBCE protein, also known as tubulin folding cofactor E, plays a crucial role in the tubulin folding pathway, specifically in the second step, where TBCE assists in the proper assembly of microtubules, which are essential components of the cytoskeletal network. Microtubules are vital for various cellular functions, including maintaining cell shape, enabling intracellular transport, and facilitating cell division. TBCE′s ability to associate with microtubules and proteasomes allows TBCE to protect against misfolded protein stress, thereby ensuring cellular integrity and function. Mutations in the TBCE gene have been linked to serious conditions such as hypoparathyroidism-retardation-dysmorphism syndrome and Kenny-Caffey syndrome type 1, highlighting TBCE′s significance in human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBCE Antibody (D-11) References:
- Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome. | Parvari, R., et al. 2002. Nat Genet. 32: 448-52. PMID: 12389028
- Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization. | Grynberg, M., et al. 2003. BMC Bioinformatics. 4: 46. PMID: 14536023
- Cryptic out-of-frame translational initiation of TBCE rescues tubulin formation in compound heterozygous HRD. | Tian, G., et al. 2006. Proc Natl Acad Sci U S A. 103: 13491-6. PMID: 16938882
- Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. | Kortazar, D., et al. 2007. Exp Cell Res. 313: 425-36. PMID: 17184771
- Hypoparathyroidism[corrected]-retardation-dysmorphism (HRD): is there a new variant not caused by a TBCE mutation? | Naguib, K., et al. 2007. Am J Med Genet A. 143A: 301-2; author reply 303-4. PMID: 17219390
- Progressive motor neuronopathy: a critical role of the tubulin chaperone TBCE in axonal tubulin routing from the Golgi apparatus. | Schaefer, MK., et al. 2007. J Neurosci. 27: 8779-89. PMID: 17699660
- Mutation in the TBCE gene is associated with hypoparathyroidism-retardation-dysmorphism syndrome featuring pituitary hormone deficiencies and hypoplasia of the anterior pituitary and the corpus callosum. | Padidela, R., et al. 2009. J Clin Endocrinol Metab. 94: 2686-91. PMID: 19491227
- Tubulin chaperone E binds microtubules and proteasomes and protects against misfolded protein stress. | Voloshin, O., et al. 2010. Cell Mol Life Sci. 67: 2025-38. PMID: 20204449
- Pathway leading to correctly folded beta-tubulin. | Tian, G., et al. 1996. Cell. 86: 287-96. PMID: 8706133
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBCE Antibody (D-11) | sc-398209 | 200 µg/ml | $322.00 | |||
TBCE Antibody (D-11) AC | sc-398209 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TBCE Antibody (D-11) HRP | sc-398209 HRP | 200 µg/ml | $322.00 | |||
TBCE Antibody (D-11) FITC | sc-398209 FITC | 200 µg/ml | $336.00 | |||
TBCE Antibody (D-11) PE | sc-398209 PE | 200 µg/ml | $349.00 | |||
TBCE Antibody (D-11) Alexa Fluor® 488 | sc-398209 AF488 | 200 µg/ml | $364.00 | |||
TBCE Antibody (D-11) Alexa Fluor® 546 | sc-398209 AF546 | 200 µg/ml | $364.00 | |||
TBCE Antibody (D-11) Alexa Fluor® 594 | sc-398209 AF594 | 200 µg/ml | $364.00 | |||
TBCE Antibody (D-11) Alexa Fluor® 647 | sc-398209 AF647 | 200 µg/ml | $364.00 | |||
TBCE Antibody (D-11) Alexa Fluor® 680 | sc-398209 AF680 | 200 µg/ml | $364.00 | |||
TBCE Antibody (D-11) Alexa Fluor® 790 | sc-398209 AF790 | 200 µg/ml | $364.00 | |||
TBCE (D-11) Neutralizing Peptide | sc-398209 P | 100 µg/0.5 ml | $69.00 |