TBC1D3/3B/3C/3G Antibody (H-7): sc-376073
- TBC1D3/3B/3C/3G Antibody (H-7) is a mouse monoclonal IgG1 κ TBC1D3/3B/3C/3G antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 496-549 mapping at the C-terminus of TBC1D3 of human origin
- TBC1D3/3B/3C/3G Antibody (H-7) is recommended for detection of TBC1D3, TBC1D3B, TBC1D3C and TBC1D3G of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TBC1D3/3B/3C/3G Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TBC1D3/3B/3C/3G Antibody (H-7) for WB and IHC(P) applications. These reagents are now offered in bundles with TBC1D3/3B/3C/3G Antibody (H-7) (see ordering information below).
TBC1D3/3B/3C/3G Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBC1D3/3B/3C/3G protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TBC1D3/3B/3C/3G (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The TBC1D3 family of proteins, which includes TBC1D3, TBC1D3B, TBC1D3C, and TBC1D3G, plays a crucial role in cellular processes by acting as GTPase-activating proteins for Rab 5, thereby regulating vesicular trafficking and endocytosis. This regulation is vital for maintaining cellular homeostasis and facilitating communication between different cellular compartments. Dysregulation of TBC1D3 proteins has been implicated in the development of various carcinomas, including prostate cancer, highlighting their potential as biomarkers for cancer progression. The genes encoding these proteins are located on human chromosome 17, a region that is significant not only for its high gene density but also for its association with key tumor suppressor genes such as p53 and BRCA1, both of which are critical for maintaining genomic stability and preventing tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBC1D3/3B/3C/3G Antibody (H-7) References:
- PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. | Pei, L., et al. 2002. Cancer Res. 62: 5420-4. PMID: 12359748
- The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. | Masuda-Robens, JM., et al. 2003. Mol Cell Biol. 23: 2151-61. PMID: 12612085
- TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. | Hodzic, D., et al. 2006. Genomics. 88: 731-736. PMID: 16863688
- The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking. | Wainszelbaum, MJ., et al. 2008. J Biol Chem. 283: 13233-42. PMID: 18319245
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. | Ishibashi, K., et al. 2009. Genes Cells. 14: 41-52. PMID: 19077034
- Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes. | Onno, M., et al. 1993. Gene. 131: 209-15. PMID: 8406013
- Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes. | Onno, M., et al. 1993. DNA Cell Biol. 12: 107-18. PMID: 8471161
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBC1D3/3B/3C/3G Antibody (H-7) | sc-376073 | 200 µg/ml | $322.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-527506 | 200 µg Ab; 10 µg BP | $361.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-532879 | 200 µg Ab; 20 µg BP | $361.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) AC | sc-376073 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) HRP | sc-376073 HRP | 200 µg/ml | $322.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) FITC | sc-376073 FITC | 200 µg/ml | $336.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) PE | sc-376073 PE | 200 µg/ml | $349.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) Alexa Fluor® 488 | sc-376073 AF488 | 200 µg/ml | $364.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) Alexa Fluor® 546 | sc-376073 AF546 | 200 µg/ml | $364.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) Alexa Fluor® 594 | sc-376073 AF594 | 200 µg/ml | $364.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) Alexa Fluor® 647 | sc-376073 AF647 | 200 µg/ml | $364.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) Alexa Fluor® 680 | sc-376073 AF680 | 200 µg/ml | $364.00 | |||
TBC1D3/3B/3C/3G Antibody (H-7) Alexa Fluor® 790 | sc-376073 AF790 | 200 µg/ml | $364.00 |