SUN2 Antibody (H-4): sc-376881

SUN2 Antibody (H-4) is a mouse monoclonal IgG2b antibody that detects SUN2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SUN2, also known as sad1/unc-84 protein-like 2, UNC84B, FRIGG, KIAA0668, or RAB5IP, is a 717 amino acid single-pass membrane protein characterized by the presence of one SUN domain, which plays a crucial role in the structural integrity and function of the nuclear envelope. SUN2 is predominantly localized to the membranes of both the nucleus and endosomes, where SUN2 is involved in essential cellular processes, including the regulation of homotypic endosome fusion through interaction with Rab 5A. The significance of SUN2 extends beyond cellular functions, as the gene encoding SUN2 is located on human chromosome 22, a region associated with various genetic disorders, including Phelan-McDermid syndrome and Neurofibromatosis type 2. Mutations in genes on this chromosome can lead to serious developmental and psychiatric conditions, highlighting the importance of SUN2 in both cellular biology and human health. With broad species reactivity and versatile applications, anti-SUN2 antibody (H-4) is an invaluable tool for researchers investigating the roles of this critical protein in various biological contexts.

The preferred SUN2 antibody is SUN2 Antibody (G-5): sc-377459.