SUN1 Antibody (2D10): sc-293292
- SUN1 Antibody (2D10) is a mouse monoclonal IgG2a κ SUN1 antibody provided at 100 µg/ml
- raised against amino acids 1-257 representing full length SUN1 of human origin
- recommended for detection of SUN1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SUN1 Antibody (2D10). This work is in progress.
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SUN1 Antibody (2D10) is a mouse monoclonal IgG2a kappa light chain antibody that detects SUN1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SUN1 antibody (2D10) is available as a non-conjugated format. SUN1, also known as UNC84A, is a multi-pass nuclear membrane protein that plays a crucial role in nuclear anchoring and migration, which are essential processes for maintaining cellular integrity and function. Highly expressed in the heart, brain, and testis, UNC84A serves as an A-type Lamin-binding protein, establishing a vital link between the inner and outer nuclear envelope membranes. This structural connection facilitates proper localization of nuclear envelope proteins and connects the nuclear interior to the actin cytoskeleton, thereby influencing cellular shape and movement. UNC84A is implicated in telomere attachment and normal testis development, highlighting its significance in both cellular organization and reproductive health. SUN1 contains one UNC84 (SUN) domain and exists in four isoforms due to alternative splicing, which may contribute to diverse functional roles within the cell.
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SUN1 Antibody (2D10) References:
- Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane. | Dreger, M., et al. 2001. Proc Natl Acad Sci U S A. 98: 11943-8. PMID: 11593002
- Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. | Bray, JD., et al. 2002. Genomics. 79: 799-808. PMID: 12036294
- The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. | Padmakumar, VC., et al. 2005. J Cell Sci. 118: 3419-30. PMID: 16079285
- Nuclear envelope localization of human UNC84A does not require nuclear lamins. | Hasan, S., et al. 2006. FEBS Lett. 580: 1263-8. PMID: 16445915
- Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. | Wang, Q., et al. 2006. DNA Cell Biol. 25: 554-62. PMID: 17132086
- Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. | Chi, YH., et al. 2007. J Biol Chem. 282: 27447-27458. PMID: 17631499
- Functional association of Sun1 with nuclear pore complexes. | Liu, Q., et al. 2007. J Cell Biol. 178: 785-98. PMID: 17724119
- Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope. | Jahed, Z., et al. 2018. Biophys J. 114: 1190-1203. PMID: 29539404
- Nuclear restriction of HIV-1 infection by SUN1. | Persaud, M., et al. 2021. Sci Rep. 11: 19128. PMID: 34580332
- Inner Nuclear Membrane Protein, SUN1, is Required for Cytoskeletal Force Generation and Focal Adhesion Maturation. | Ueda, N., et al. 2022. Front Cell Dev Biol. 10: 885859. PMID: 35663386
- Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation. | Buglak, DB., et al. 2023. Elife. 12: PMID: 36989130
- SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis. | Baskerville, V., et al. 2024. Brain. 147: 109-121. PMID: 37639327
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SUN1 Antibody (2D10) | sc-293292 | 100 µg/ml | $322.00 |