아미노 산 85-244 mapping within an internal region of SMCR7 of mouse 의하고 기원한다
안티-SMCR7 항체 (A-5)는 WB, IP, IF and ELISA으로 mouse and rat유래의 SMCR7 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-SMCR7 항체 (A-5)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SMCR7 Antibody (A-5) for WB applications. These reagents are now offered in bundles with SMCR7 Antibody (A-5) (see ordering information below).
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SMCR7 Antibody (A-5) is a high quality monoclonal SMCR7 antibody (also designated SMCR7 antibody) suitable for the detection of the SMCR7 protein of mouse and rat origin. SMCR7 Antibody (A-5) is available as both the non-conjugated anti-SMCR7 antibody form, as well as multiple conjugated forms of anti-SMCR7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Smith-Magenis syndrome (SMS) is a rare disorder that is characterized by multiple congenital anomalies and mental retardation, with associated sleep disturbance and behavioral abnormalities. Autistic-like behaviors and symptoms begin to develop at about 18 months of age. Although there is no cure for SMS, treatment focuses on the management of its symptoms such as treating sleep disturbance, management of behaviors, speech and occupational therapies, as well as minor medical interventions. The genetic locus of 17p11.2 is deleted in patients affected with SMS. Many studies have linked the disorder to the haploinsufficiency of the retinoic acid-induced 1 (RAI1) gene that maps within the Smith-Magenis chromosome region. SMCR7 (Smith-Magenis syndrome chromosomal region candidate gene 7) is a 454 amino acid single-pass membrane protein that is encoded by a gene that also maps within the critical region of deletion in SMS. SMCR7 is expressed in all tissues with highest expression in skeletal muscle and heart. There are two isoforms of SMCR7 that are produced as a result of alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
What is the recommended starting dilution for Western blot for SMCR7 (A-5): sc-515759 monoclonal antibody?
Asked by: Trav11
Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link:
If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.