Molecular structure of Selumetinib, CAS Number: 606143-52-6
Selumetinib (CAS 606143-52-6)
See product citations (5)
Alternate Names:
AZD6244
Application:
Selumetinib is a MEK-1 non-ATP competitive inhibitor
CAS Number:
606143-52-6
Purity:
≥98%
Molecular Weight:
457.68
Molecular Formula:
C17H15BrClFN4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selumetinib is a compound extensively studied for its role in various signaling pathways, specifically the MAPK/ERK pathway, which is integral in cell division and proliferation. In research applications, it is utilized as a tool to understand the biological consequences of inhibiting this pathway in different cell types. Investigations into the molecular mechanisms that govern cellular response to environmental stress often incorporate selumetinib due to its ability to modulate intracellular signaling cascades. Furthermore, in cancer research, selumetinib is applied to in vitro models to examine its effects on tumor growth and survival, providing insights into the molecular underpinnings of oncogenesis. Its role in research extends to the study of its interactions with other cellular proteins and the potential downstream effects of its application in various biological systems.
Selumetinib (CAS 606143-52-6) References
- Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma. | Patel, SP. and Kim, KB. 2012. Expert Opin Investig Drugs. 21: 531-9. PMID: 22394161
- Selumetinib in advanced non small cell lung cancer (NSCLC) harbouring KRAS mutation: endless clinical challenge to KRAS-mutant NSCLC. | Paolo, M., et al. 2013. Rev Recent Clin Trials. 8: 93-100. PMID: 24063423
- Profile of selumetinib and its potential in the treatment of melanoma. | Kim, DW. and Patel, SP. 2014. Onco Targets Ther. 7: 1631-9. PMID: 25278770
- Selumetinib for the treatment of metastatic uveal melanoma: past and future perspectives. | Komatsubara, KM., et al. 2016. Future Oncol. 12: 1331-44. PMID: 27044592
- Selumetinib for the treatment of non-small cell lung cancer. | Casaluce, F., et al. 2017. Expert Opin Investig Drugs. 26: 973-984. PMID: 28675058
- Selumetinib Shrinks Tumors in Neurofibromatosis. | . 2020. Cancer Discov. 10: OF10. PMID: 32284324
- Treating non-small cell lung cancer with selumetinib: an up-to-date drug evaluation. | Imyanitov, EN., et al. 2020. Expert Opin Pharmacother. 21: 1943-1953. PMID: 32880495
- Clinical Pharmacokinetics and Pharmacodynamics of Selumetinib. | Campagne, O., et al. 2021. Clin Pharmacokinet. 60: 283-303. PMID: 33354735
- Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib. | Galvin, R., et al. 2021. Curr Oncol Rep. 23: 45. PMID: 33721151
- Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity. | Huang, HJ., et al. 2021. Sci Rep. 11: 12497. PMID: 34127699
- Selumetinib: a selective MEK1 inhibitor for solid tumor treatment. | Hedayat, M., et al. 2023. Clin Exp Med. 23: 229-244. PMID: 35171389
- Selumetinib for Refractory Pulmonary and Gastrointestinal Bleeding in Noonan Syndrome. | Chakraborty, A., et al. 2022. Pediatrics. 150: PMID: 36082608
Inhibitor of:
α-centractin, β-defensin 28, β-defensin 37, β-defensin 40, 1500010J02Rik, 1500032L24Rik, 1700090G07Rik, 2900053A13Rik, 3110052M02Rik, 9330182O14Rik, AHNAK, ARMCX3, Bu-b, C11orf55, C12orf73, C130060K24Rik, C230099D08Rik, C2orf29_D1Bwg0212e, C330019G07Rik, C330019L16Rik, C330021F23Rik, C35, C5orf55, Cactin, Capicua, CCDC102B, CCDC117, CCDC13, CCDC157, CCDC39, CCDC71, Cdx1, CECR4, CECR6, CNK1, CNK2, CNKSR3, cortexin 2, CSN8, CXorf22, CYHR1, Cypt3, D530049N12Rik, DAN, DDX3Y, DLD, DOCK 8, E2F-5, EF-CAB3, EG231736, EG245440, EG626215, ERK 4, EVI2B, EWS, FAM131B, FAM149B1, FAM75C1, FLJ36848, FLRT2, FOXL2, FSD1, G3BP1, gankyrin, GCET2, GIDRP88, Gm1027, Gm128, Gm14325, Gm3696, Gm9766, GOLGA6L6, GPR172C, GSDMDC1, HACE1, Headpin, ICAM-2, IL-28R, ILT-4, KIAA0513, KRBA1, KRI1, LIN-3, LOC100041208, LOC100041224, LOC100041231, LOC100041261, LOC100041358, LOC339047, LOC641696, LZTR1, MADD, MAGE-A12, MAGE-C3, MANBAL, MAPKBP-1, Max, MEAF6, mEH, MEK kinase-1, MEK kinase-2, MEK kinase-4, MEK-1, MEK-4, MEK-5, MEK1, MEK2, Mel-CAM, Melan-A, Melanoma Marker, Meteorin, MGC14376, Mig12, MLTK, Mnk2, Mos, Mpk1, MTDH, Myeov, N-SMase2, NARF, NURIM, Olfr539, Olfr549, Olfr55, Olfr550, Olfr575, Olfr577, Olfr583, Olfr720, Olfr834, Olr1064, Olr107, Olr1155, Olr1217, Olr125, Olr1307, Olr157, Olr1630, Olr164, Olr175, Olr223, Olr272, Olr307, Olr363, Olr382, Olr532, Olr655, Olr707, Olr749, Olr80, Olr836, Olr879, Olr889, Olr964, Ott, OTTMUSG00000002040, OTTMUSG00000002042, OTTMUSG00000002045, OTTMUSG00000002180, OTTMUSG00000002191, OTTMUSG00000002200, OTTMUSG00000002201, OTTMUSG00000002543, OTTMUSG00000003605, OTTMUSG00000003606, OTTMUSG00000003947, OTTMUSG00000004010, OTTMUSG00000004012, OTTMUSG00000004013, OTTMUSG00000004461, OTTMUSG00000004551, OTTMUSG00000005148, OTTMUSG00000005215, OTTMUSG00000005288, OTTMUSG00000005304, OTTMUSG00000005931, OTTMUSG00000010332, OTTMUSG00000010432, OTTMUSG00000017976, OTTMUSG00000018258, OTTMUSG00000019267, OTTMUSG00000019786, OVCA1, PAGE-4, PB1, Pbx 2, PCDH7, PD-2, Pelle, PHTF2, podoplanin, PRL-3, Pumilio 2, Rab L3, Raf-1, Raf-B, Ras-GRF2, RASGEF1A, RASSF1, RASSF3, RGL1, RREB1, SBNO1, SCO1, SCOP, Scpppq1, Shc, SKRP1, SPINK13, SPRED1, SPRED2, Sprouty 4, SPZ1, SS18L2, STAP-2, STC2, Ste7, T2BP, TAL1, TBX18, TESSP-1, TEX19.1, Tmem217, TREM-2c, TRIQK, TWISTNB, TXNDC15, Vmn1r204, WDR21C, WDR55, WDSOF1, XAGE-1C, XEDAR, XXYLT1, ZNF726, and ZSCAN5B.Activator of:
ALY, BOB_GPR15, c-Erb-A α-2, c-Erb-A β-1, C030039L03Rik, C030046E11Rik, Cot, EG546272, EG546282, EGFL3, FANCI, FGF-5, FNDC3B, FRNK, GPNMB, KIR3.4, KLC1, Krs-2, MAGI-3, MFAP3L, MOBKL2B, NAB2, NARC-1, Pdcd-1L1, PRRG1, PUMA, Rab 5B, raf-A, RAO, SCOCO, and TSSK 1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Selumetinib, 5 mg | sc-364613 | 5 mg | $29.00 | |||
Selumetinib, 10 mg | sc-364613A | 10 mg | $82.00 | |||
Selumetinib, 100 mg | sc-364613B | 100 mg | $420.00 | |||
Selumetinib, 500 mg | sc-364613C | 500 mg | $1897.00 | |||
Selumetinib, 1 g | sc-364613D | 1 g | $3021.00 |