(S)-Pramipexole (CAS 104632-26-0)

건강 상태 :

Solid

용해도 :

Soluble in methanol.

저장 :

Store at -20° C

녹는점 :

127-128° C (lit.)

비등점 :

377.99° C at 760 mmHg (Predicted)

밀도 :

1.17 g/cm³ (Predicted)

굴절률 :

n²⁰_D 1.58 (Predicted)

광학 활동 :

α20_D -93.85, c = 1 in methanol

IC50 :

Dopamine D1 receptor: IC₅₀ = 4.7 µM (rat); Dopamine D5 receptor: IC₅₀ = 4.7 µM (rat); Dopamine D4 receptor: IC₅₀ = 4.7 µM (rat); Dopamine D3 receptor: IC₅₀ = 4.7 µM (rat); Dopamine D2 receptor: IC₅₀ = 4.7 µM (rat); Dopamine D3 receptor: EC₅₀50 = 1.5 nM (human); Dopamine D2 receptor: EC₅₀50 = 5 nM (human)

Ki 데이타 :

Dopamine D3 receptor: K_i= 0.78 nM (rat); Dopamine D3 receptor: K_i= 0.87 nM (human); Dopamine D2 receptor: K_i= 3.1 nM (rat); Dopamine D4 receptor: K_i= 8.1 nM (human); Dopamine D2 receptor: K_i= 21 nM (human)

pK 값 :

pK_b: 9.47 (Predicted)

PubChem CID :

MDL 번호 :

MFCD00869076

Beilstein 기재 :

6479326

SMILES :

CCCN[C@H]1CCC2=C(C1)SC(=N2)N