Date published: 2025-9-8

001 800-1338-3838

SCBT Portrait Logo
Seach Input

RUNX2 항체 (F-2): sc-390351

4.6(28)
리뷰 쓰기질문하기

데이터 시트
  • RUNX2 항체 F-2 는 마우스 monoclonal IgG1 κ RUNX2 항체, 141간행물에 인용, 이며 200 µg/ml으로 제공합니다.
  • mouse origin의 RUNX2에서 내부에 위치한 294-363 아미노산을 항원으로 사용하였습니다.
  • RUNX2 항체 (F-2)는 WB, IP, IF, IHC(P) and ELISA으로 mouse, rat and human유래의 RUNX2 를 감지하는 데에 추천한다.; 이외에, equine, bovine and porcine등 species와 반응할수 있습니다
  • 항-RUNX2 항체(F-2)는 IP용 agarose와 결합되어 이용 가능하며, WB, IHC(P), ELISA용 HRP와 결합되어 이용 가능하며, IF, IHC(P), FCM용 phycoerythrin 또는 FITC와 결합되어 이용 가능합니다.
  • WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
  • WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
  • Gel Supershift와 ChIP 에 사용하는 TransCruz시약(sc-390351 X, 200 µg/0.1 ml)이 있습니다.
  • RUNX2 (F-2): sc-390351무료10 µg 샘플을 신청하려면 기술지원팀 (또는 로컬 디스트리뷰터)에 연락주세요.
  • m-IgG Fc BP-HRP 는 RUNX2 항체 (F-2) 가WB and IHC(P) 에 응용될 때 우선으로 사용하는 이차 항체 검사 시약입니다.이 시약은RUNX2 항체(F-2) 와 세트로 제공드립니다. (아래의 주문 정보를 참고해 주시길 바랍니다)。

빠른 링크

더보기

RUNX2 항체(F-2)는 마우스, 쥐 및 인간 유래의 RUNX2 단백질을 WB, IP, IF, IHC(P) 및 ELISA로 검출하는 IgG1 κ 마우스 모노클로날 RUNX2 항체(CBFA1 항체, AML3 항체 또는 PEBP2A 항체로도 지정됨)입니다. RUNX2 항체(F-2)는 비접합 항체 형태뿐만 아니라 아가로스, HRP, PE, FITC 및 여러 Alexa Fluor® 접합체를 포함한 여러 접합 형태의 항체로도 제공됩니다. 포유류 런트 관련 전사인자(RUNX) 계열은 RUNX1(AML-1, PEBP2αB, CBFA2로도 지정), RUNX2(AML-3, PEBP2αA, CBFA1, Osf2로도 지정) 및 RUNX3(AML-2, PEBPαC, CBFA3로도 지정)의 세 가지 구성 요소로 이루어져 있습니다. RUNX 계열은 세포 분화 및 세포 주기 진행에 관여하는 유전자의 발현을 조절하는 DNA 결합 단백질입니다. RUNX2는 중간엽 줄기세포의 조골세포 분화를 자극하고 연골세포 비대를 촉진하며 내피세포 이동과 발달 중인 뼈의 혈관 침입에 기여한다는 점에서 골격 무기질화에 필수적입니다. RUNX2 발현을 조절하는 것은 뼈 형성을 촉진하는 데 유용한 치료 도구가 될 수 있습니다. RUNX2의 C-말단에 있는 돌연변이는 상염색체 우성 골격 이형성증 증후군인 클레도두개골 이형성증후군과 관련이 있으며, 이는 광범위한 종아리 봉합, 쇄골 저형성증, 과잉치 및 단신으로 특징지어집니다.

연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

Alexa Fluor®는 미국 오리건주 Molecular Probes Inc.의 상표입니다.

LI-COR®와 Odyssey®는 LI-COR Biosciences의 등록 상표입니다.

RUNX2 항체 (F-2) 참고문헌:

  1. 유방암 발병에서 RUNX2의 역할.  |  Wysokinski, D., et al. 2015. Int J Mol Sci. 16: 20969-93. PMID: 26404249
  2. 두개골기형증과 RUNX2-임상 표현형-유전자형 상관관계.  |  Jaruga, A., et al. 2016. Clin Genet. 90: 393-402. PMID: 27272193
  3. 골아세포 분화에서 마이크로RNA에 의한 Runx2 조절.  |  Narayanan, A., et al. 2019. Life Sci. 232: 116676. PMID: 31340165
  4. Runx2 의존적 골격 발달의 분자적 메커니즘.  |  Komori, T. 2020. Mol Cells. 43: 168-175. PMID: 31896233
  5. RUNX2는 BMP4 신호 전달 경로를 통해 조골세포 분화를 조절합니다.  |  Liu, DD., et al. 2022. J Dent Res. 101: 1227-1237. PMID: 35619284
  6. Runx2는 신생아 단계에서 골아세포 프로그램을 지시하기 위해 염색질 접근성을 조절합니다.  |  Hojo, H., et al. 2022. Cell Rep. 40: 111315. PMID: 36070691
  7. Runx2와 Runx3은 수술로 유발된 골관절염 발생 과정에서 관절 연골세포를 다르게 조절한다.  |  Nagata, K., et al. 2022. Nat Commun. 13: 6187. PMID: 36261443
  8. 4-하이드록시노네날에 의한 K176에서의 Runx2의 카르보닐화는 혈관 석회화를 촉진합니다.  |  Zhai, X., et al. 2024. Circulation. 149: 1752-1769. PMID: 38348663
  9. FOXO1은 석회화된 대동맥 판막 질환에서 SMURF2를 통해 RUNX2 유비퀴틴화를 조절합니다.  |  Jiang, C., et al. 2024. Redox Biol. 73: 103215. PMID: 38810422
  10. 인간 암의 예후 인자로서의 RUNX2.  |  Toner, J., et al. 2024. Crit Rev Eukaryot Gene Expr. 34: 51-66. PMID: 39072409

주문정보

제품명카탈로그 번호 단위가격수량관심품목

RUNX2 항체 (F-2)

sc-390351
200 µg/ml
$316.00

RUNX2 (F-2): m-IgG Fc BP-HRP 번들

sc-526149
200 µg Ab; 10 µg BP
$354.00

RUNX2 항체 (F-2) X

sc-390351 X
200 µg/0.1 ml
$316.00

RUNX2 항체 (F-2) AC

sc-390351 AC
500 µg/ml, 25% agarose
$416.00

RUNX2 항체 (F-2) HRP

sc-390351 HRP
200 µg/ml
$316.00

RUNX2 항체 (F-2) FITC

sc-390351 FITC
200 µg/ml
$330.00

RUNX2 항체 (F-2) PE

sc-390351 PE
200 µg/ml
$343.00

RUNX2 항체 (F-2) Alexa Fluor® 488

sc-390351 AF488
200 µg/ml
$357.00

RUNX2 항체 (F-2) Alexa Fluor® 546

sc-390351 AF546
200 µg/ml
$357.00

RUNX2 항체 (F-2) Alexa Fluor® 594

sc-390351 AF594
200 µg/ml
$357.00

RUNX2 항체 (F-2) Alexa Fluor® 647

sc-390351 AF647
200 µg/ml
$357.00

RUNX2 항체 (F-2) Alexa Fluor® 680

sc-390351 AF680
200 µg/ml
$357.00

RUNX2 항체 (F-2) Alexa Fluor® 790

sc-390351 AF790
200 µg/ml
$357.00

Do you have a RUNX2 antibody that reacts with sheep bone in IHC-P

Asked by: Liska
Thank you for your question. Anti-RUNX2 Antibody (C-12) sc-390715 is recommended for detection of RUNX2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, bovine, porcine and canine. RUNX2 Antibody (F-2) sc-390351 is recommended for detection of RUNX2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, bovine and porcine. Neither of these antibodies has been tested on sheep cell or tissue samples so we cannot say whether or not it would also be reactive in such a setup.
Answered by: Tech Support Europe
Date published: 2024-03-28

does RUNX2 Antibody (F-2): sc-390351 antibody work in tissue from dogs and cats?

Asked by: Rphtorres
Thank you for your question. We would not recommend this antibody for dog or cat samples . There is a 68%homology in dog and 45% homology in cat.
Answered by: BlakeJ
Date published: 2023-07-11

This antibody works very well in IF when I use anti-mouse IGG or IGG1, but it doesn't when I use IGG2b. Are you sure it is IGG2b? I don't think so. Thanks

Asked by: chicobotelho
Thank you for your question. Also, thank you for noticing that we had the wrong isotype for this antibody, we had missed that error. It has since been fixed!
Answered by: Technical Support
Date published: 2022-06-10

what about the price of this antibody?

Asked by: miniminxi
For accurate availability, pricing and shipping information regarding this product, please contact customer service.
Answered by: Tech Service
Date published: 2019-01-04

I have Runx2 ab tag with fluor 488, my question is can I use the ab for western blot detection.

Asked by: amira raudhah
Thank you for your question. Yes, this antibody is fine for WB, and the antibody conjugated with AF488 is fine for use in WB as long as you have the capability to detect that wavelength signal. If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-11-28

Can this antibody be used for IHC or IF on mouse tissue samples?

Asked by: Anna99
You can stain mouse tissue by using a directly conjugated primary antibody. RUNX2 Antibody (F-2) is available conjugated to HRP (sc-390351 HRP), 200 µg/ml, for WB, IHC(P) and ELISA; phycoerythrin (sc-390351 PE), fluorescein (sc-390351 FITC), Alexa Fluor® 488 (sc-390351 AF488) or Alexa Fluor® 647 (sc-390351 AF647), 200 µg/ml, for IF, IHC(P) and FCM.
Answered by: Technical Support 6
Date published: 2017-01-11

What is the best secondary to use with this mouse primary antibody for WB?

Asked by: Anna99
We recommend using our Mouse IgG kappa Binding Protein HRP, sc-516102. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 6
Date published: 2017-01-11
  • y_2025, m_9, d_7, h_4CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_7
  • loc_ko_KR, sid_390351, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 110ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Great results on canine osteosarcomaWe tested the antibody with a 1:150 concentration. It works after HIER.
Date published: 2023-01-19
Rated 5 out of 5 by from Very good results in WB and IFWorks very good in Western Blot and immunofluorescence (4% PFA fixation). Tested on mouse cells.
Date published: 2021-06-25
Rated 5 out of 5 by from RUNX2 (F-2): sc-390351An excellent result was obtained in Western blotting and immunofluorescence in bone marrow stem cells (BMSC)
Date published: 2021-06-15
Rated 5 out of 5 by from RunX2 (F-2) antibodyRunX2 (F-2) antibody worked nicely with animal heart samples at a 1:200 dilution.
Date published: 2018-03-29
Rated 4 out of 5 by from 比较适合WB做Western blot结果还可以。IHC我主要用来检测osteoblast中的Runx2表达,在幼龄小鼠(1week以下)组织中结果比较好,年龄较大的小鼠会出现一些非特异性信号。
Date published: 2017-12-18
Rated 5 out of 5 by from Good antibody for WBI used 1:300 dilution of the antibody on osseous tissue overnight at 4 degrees.
Date published: 2017-10-24
Rated 5 out of 5 by from The antibody is very niceRUNX2 Antibody worked well in the mouse, the background is transparent and simple operation, which has been more applications.
Date published: 2017-10-16
Rated 3 out of 5 by from Canine SamplesThis antibody work fine with canine OS cell lines at 1:500
Date published: 2017-10-10
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_28
  • loc_ko_KR, sid_390351, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
RUNX2 항체 (F-2) is rated 4.6 out of 5 by 28.
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_28
  • loc_ko_KR, sid_390351, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 115ms
  • REVIEWS, PRODUCT