Reserpine CAS: 50-55-5
MF: C33H40N2O9
MW: 608.68
An inhibitor of transport of biogenic amines into adrenal chromaffin granules.

Reserpine (CAS 50-55-5)

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Alternate Names: Serpalan; Serpasil; Hiserpia; Serpanray; Serpivite; Apoplon
Application Reserpine is an inhibitor of transport of biogenic amines into adrenal chromaffin granules
CAS 등록번호: 50-55-5
순도: ≥98%
분자량: 608.68
분자식: C33H40N2O9
추가 정보: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Reserpine has displayed a capacity to inhibit the transport of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The mechanism behind this inhibition has been illuminated as an irreversible binding to the vesicular amine transporter. Furthermore, Reserpine has been reported to interfere with dopamine transporter activity and potently inhibit synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2.


References

1. Schuldiner, S., et al. 1993. J. Biol. Chem. 268: 29-34. PMID: 8416935
2. Heslop, K.E., et al. 1999. Neuropharmacology. 38: 883-891. PMID: 10465692
3. Metzger, R.R., et al. 2002. Eur. J. Pharmacol. 456: 39-43. PMID: 12450567

Physical State :
Solid
용해도 :
Soluble in DMSO (100 mM), chloroform (10 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
저장 :
Store at room temperature
녹는점 :
264.5° C
비등점 :
~700.1° C at 760 mmHg (Predicted)
밀도 :
1.33 g/cm3 (Predicted)
굴절률 :
n20D 1.62 (Predicted)
Optical Activity :
α20/D -106.2°, c = 1 in chloroform; α23/D -118°, c = 1 in chloroform; α26/D -168°, c = 0.62 in DMF; α26/D -164°, c = 0.96 in pyridine
IC50 :
Mdr-1: IC50 = 0.5 µM (human); Plasmodium falciparum: IC50 = 0.79 µM; Sodium channel alpha subunits; brain (Types I, II, III): IC50 = 1.6 µM (human); Quinolone resistance protein norA: IC50 = 7 µM (Staphylococcus aureus); BSEP: IC50 = 10.2 µM (human)
Ki 데이타 :
Synaptic vesicular amine transporter: Ki= 1 nM (bovine); Mdr-1: Ki= 100 nM (human); MOR-1: Ki= 1.69 µM (human); P-glycoprotein 3: Ki= 4.03 µM (mouse)
pK Values :
pKa: 6.6, pKb: 7.25 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
ZG0350000
PubChem CID :
Merck Index :
14: 8145
MDL Number :
MFCD00005091
EC Number :
200-047-9
Beilstein Registry :
102014
SMILES :
COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

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Reserpine (CAS 50-55-5)  논문정보

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인용 1 to 1 of 1 합계

PMID: # 22508860  Yamamoto, T. et al. 2012. Infect. Immun. 80: 2323-32.

인용 1 to 1 of 1 합계
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