R788 CAS: 901119-35-5
MF: C23H26FN6O9P
MW: 580.46
An inhibitor to spleenic kinase-mediated IgG Fc receptor signaling.

R788 (CAS 901119-35-5)

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Alternate Names: Fostamatinib; (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate
Application R788 is an inhibitor to spleenic kinase-mediated IgG Fc receptor signaling
CAS 등록번호: 901119-35-5
순도: ≥98%
분자량: 580.46
분자식: C23H26FN6O9P
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. R788 inhibits the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. In one study, inhibition of BCR signaling with R788 affected the growth of certain leukemia cell lines. These leukemia cells express stereotyped BCRs that react with auto-antigens exposed on the surface of senescent or apoptotic cells, suggesting that they are antigen driven.

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Powder
Physical State :
Solid
저장 :
Store at -20° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
11671467
SMILES :
CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

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Citations 1 to 1 of {3} total

PMID: # 28036370  PLoS Pathog. 12: e1006139.

Citations 1 to 1 of {3} total
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