항원결정부는 human origin의 PYK2의 내부에 위치한 980-1009의 아미노산에 해당됩니다.
안티-PYK2 항체 (E-3)는 WB, IP, IF and ELISA으로 mouse, rat and human유래의 PYK2 를 감지하는 데에 추천한다.; 이외에, equine, canine and porcine등 species와 반응할수 있습니다
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-PYK2 항체 (E-3)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for PYK2 Antibody (E-3) for WB applications. This reagent is now offered in a bundle with PYK2 Antibody (E-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PYK2 Antibody (E-3) is a high quality monoclonal PYK2 antibody (also designated PTK2B antibody, FAK2 antibody, or RAFTK antibody) suitable for the detection of the PYK2 protein of mouse, rat and human origin. PYK2 Antibody (E-3) is available as both the non-conjugated anti-PYK2 antibody form, as well as multiple conjugated forms of anti-PYK2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Focal adhesion kinase (FAK) was initially identified as a substrate for the intrinsic protein tyrosine kinase activity of Src-encoded pp60. The deduced amino acid sequence of FAK p125 has shown it to be a cytoplasmic protein tyrosine kinase whose sequence and structural organization are unique compared to other protein families described. A putative new member of the FAK family, designated PYK2 (proline-rich tyrosine kinase 2), exhibits 61% sequence identity with FAK over its kinase domain. PYK2 (also designated CAKb or RAFTK) is highly expressed in the central nervous system. Activation of the kinase leads to modulation of ion channel function and the activation of the MAPK signaling pathway. PYK2 is rapidly phosphorylated on tyrosine residues in response to stimuli that increase intracellular calcium levels and compounds that activate members of the PKC family of kinases, such as phorbol esters.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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