POSH Antibody (YY-5): sc-100815

POSH Antibody (YY-5) is a mouse monoclonal IgG2a antibody that detects POSH in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). POSH, which stands for "plenty of SH3s," is a crucial protein that contains four SH3 domains and plays a significant role in cellular signaling pathways. Anti-POSH antibody (YY-5) preferentially interacts with the GTP-bound form of Rac, a member of the small GTPase family, thereby acting as a molecular switch that regulates actin dynamics and stress fiber formation. POSH mediates the activation of c-Jun N-terminal kinase (JNK) and the nuclear translocation of nuclear factor kappa B (NFkB), both of which are vital for various cellular processes, including apoptosis and stress responses. By facilitating these signaling events, POSH contributes to the intricate network of cellular communication and response to external stimuli, making POSH a key player in maintaining cellular homeostasis and influencing cell fate decisions. POSH monoclonal antibody (YY-5) serves as an essential tool for researchers investigating the roles of Rac and its downstream effects in various biological contexts.

The preferred POSH antibody is POSH Antibody (E-1): sc-390103.