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Poly[(R)-3-hydroxybutyric acid] (CAS 29435-48-1)

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Alternate Names:
(R)-3-Hydroxybutyric acid polymerized; PHB;
CAS Number:
29435-48-1
Molecular Formula:
[COCH2CH(CH3)O]n
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Poly[(R)-3-hydroxybutyric acid] (PHB) is a biodegradable and bioresorbable polyester derived from naturally occurring 3-hydroxybutyric acid (3HB). With its biocompatible nature, PHB has found diverse applications in drug delivery, tissue engineering, and medical devices. It serves as a biobased polyester, contributing to the development of biodegradable plastics, coatings, adhesives, medical devices, and drug delivery systems. Extensive research has explored the potential of Poly[(R)-3-hydroxybutyric acid] (natural origin) in various scientific and medical realms. It has demonstrated promise as a scaffold material for tissue engineering, offering biocompatibility, biodegradability, and bioresorbability. Additionally, Poly[(R)-3-hydroxybutyric acid] (natural origin) has been investigated as a coating material for medical implants, delivering non-toxic properties and the ability to be modified for specific needs. While the precise mechanism of action remains partially understood, it is known that Poly[(R)-3-hydroxybutyric acid] (natural origin) is susceptible to enzymatic breakdown and other biological processes. Furthermore, its properties can be tailored to enhance solubility and mechanical strength.


Poly[(R)-3-hydroxybutyric acid] (CAS 29435-48-1) References

  1. Structural effects on enzymatic degradabilities for poly[(R)-3-hydroxybutyric acid] and its copolymers.  |  Abe, H. and Doi, Y. 1999. Int J Biol Macromol. 25: 185-92. PMID: 10416666
  2. Microbial degradation of polyesters.  |  Jendrossek, D. 2001. Adv Biochem Eng Biotechnol. 71: 293-325. PMID: 11217416
  3. High-resolution solid-state 13C NMR studies of poly[(R)-3-hydroxybutyric] acid.  |  Nozirov, F., et al. 2002. Solid State Nucl Magn Reson. 21: 197-203. PMID: 12199361
  4. One-step synthesis of amphiphilic diblock copolymers from bacterial poly([R]-3-hydroxybutyric acid).  |  Ravenelle, F. and Marchessault, RH. 2002. Biomacromolecules. 3: 1057-64. PMID: 12217053
  5. Kinetic studies and biochemical pathway analysis of anaerobic poly-(R)-3-hydroxybutyric acid synthesis in Escherichia coli.  |  Carlson, R., et al. 2005. Appl Environ Microbiol. 71: 713-20. PMID: 15691921
  6. Enzymatic degradation processes of poly[(R)-3-hydroxybutyric acid] and poly[(R)-3-hydroxybutyric acid-co-(R)-3-hydroxyvaleric acid] single crystals revealed by atomic force microscopy: effects of molecular weight and second-monomer composition on erosion rates.  |  Numata, K., et al. 2005. Biomacromolecules. 6: 2008-16. PMID: 16004439
  7. Adsorption and hydrolysis reactions of poly(hydroxybutyric acid) depolymerases secreted from Ralstonia pickettii T1 and Penicillium funiculosum onto poly[(R)-3-hydroxybutyric acid].  |  Numata, K., et al. 2007. Biomacromolecules. 8: 2276-81. PMID: 17547455
  8. Efficient secretion of (R)-3-hydroxybutyric acid from Halomonas sp. KM-1 by nitrate fed-batch cultivation with glucose under microaerobic conditions.  |  Kawata, Y., et al. 2014. Bioresour Technol. 156: 400-3. PMID: 24503050
  9. Improvement of (R)-3-hydroxybutyric acid secretion during Halomonas sp. KM-1 cultivation with saccharified Japanese cedar by the addition of urea.  |  Kawata, Y., et al. 2015. Lett Appl Microbiol. 61: 397-402. PMID: 26249654
  10. Absolute quantitation of poly(R)-3-hydroxybutyric acid using spectrofluorometry in recombinant Escherichia coli.  |  Rajankar, MP., et al. 2018. Biol Methods Protoc. 3: bpy007. PMID: 32161801
  11. Morphology and biodegradability of a binary blend of poly((R)-3-hydroxybutyric acid) and poly((R,S)-lactic acid).  |  Koyama, N. and Doi, Y. 1995. Can J Microbiol. 41 Suppl 1: 316-22. PMID: 7606667
  12. Characterization of the cell response of cultured macrophages and fibroblasts to particles of short-chain poly[(R)-3-hydroxybutyric acid].  |  Saad, B., et al. 1996. J Biomed Mater Res. 30: 429-9. PMID: 8847351
  13. Biodegradation of polyhydroxyalkanoic acids.  |  Jendrossek, D., et al. 1996. Appl Microbiol Biotechnol. 46: 451-63. PMID: 9008883
  14. Molecular mass of poly[(R)-3-hydroxybutyric acid] produced in a recombinant Escherichia coli.  |  Kusaka, S., et al. 1997. Appl Microbiol Biotechnol. 47: 140-3. PMID: 9077002

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Poly[(R)-3-hydroxybutyric acid], 250 mg

sc-255438B
250 mg
$42.00

Poly[(R)-3-hydroxybutyric acid], 1 g

sc-255438A
1 g
$67.00

Poly[(R)-3-hydroxybutyric acid], 10 g

sc-255438
10 g
$176.00