Perindoprilat CAS: 95153-31-4
MF: C17H28N2O5
MW: 340.41
An angiotensin-converting enzyme (ACE) inhibitor.

Perindoprilat (CAS 95153-31-4)

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Alternate Names: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; [2S-[1[R*(R*)],2α,3aβ,7aβ]]-1-[2-[(1-Carboxybutyl)amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; S 9780; USP Perindopril Related Compound B
Application Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor
CAS 등록번호: 95153-31-4
분자량: 340.41
분자식: C17H28N2O5
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).

Perindoprilat is an active metabolite of Perindopril (sc-205799), an ACE (angiotensin converting enzyme) inhibitor, which modulates the activity of low density lipoprotein receptor-related protein (LRP). LRP is a multifunctional endocytic receptor, which functions in the turnover of proteases and the degradation of extracellular matrix proteins. It is known that Perindoprilat inhibits the conversion of angiotensin I into angiotensin II, which lowers arteriolar pressure and increases venous capacity.


References

1. Bree, F., et al. 1992. Int J Clin Pharmacol Ther Toxicol. 30: 325-330. PMID: 1330941
2. Pawluczyk, I.Z., et al. 2008. J. Biol. Chem. 283: 4588-4594. PMID: 18156630

Physical State :
Solid
용해도 :
Soluble in ethanol, methanol, and water.
저장 :
Store at -20° C
녹는점 :
136-140° C
비등점 :
~568.1° C at 760 mmHg (Predicted)
밀도 :
~1.2 g/cm3 (Predicted)
굴절률 :
n20D 1.54 (Predicted)
pK Values :
pKa: 2.27 (Predicted), pKb: 8.13 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
RTECS :
ND6007250
PubChem CID :
72022
MDL Number :
MFCD00865777
SMILES :

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PMID: # 28666228  van der Nagel, BCH. et al. 2017. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1060: 367-373.

PMID: # 27422988  Flavahan, S. et al. 2016. Am. J. Physiol. Heart Circ. Physiol. 311: H849-54.

PMID: # 25485905  Zhao, Y. et al. 2015. Am. J. Physiol. Heart Circ. Physiol. 308: H358-63.

PMID: # 21411099  Shintani, Y. et al. 2011. Atherosclerosis. 216: 307-12.

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