PD 166866 CAS: 192705-79-6
MF: C20H24N6O3
MW: 396.44
An inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for bFGF.

PD 166866 (CAS 192705-79-6)

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Application PD 166866 is an inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for bFGF
CAS 등록번호: 192705-79-6
순도: 98%
분자량: 396.44
분자식: C20H24N6O3
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

PD 166866 is a potent inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for FGF-2 (bFGF). It has no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases, or MEK, PKC, or CDK4. PD 166866 is an inhibitor of Flg (FGFR1).


References

Zhu, X., et al.: Science, 251, 90 (1991), Davies, D.E., et al.: Biochem. Pharmacol., 51, 1101 (1996), Panek, R.L., et al.: J. Pharmacol. Exp. Ther., 286, 569 (1998), Iacoangeli, A., et al.: Biochimie, 82, 35 (2000),

Physical State :
Solid
용해도 :
Soluble in DMSO (≥10 mg/ml).
저장 :
Store at -20° C
녹는점 :
291-293°C (lit.)
밀도 :
1.28 g/cm3 (Predicted)
굴절률 :
n20D 1.64 (Predicted)
IC50 :
Fibroblast growth factor receptor 1: IC50 = 48 nM (human); c-Src : IC50 = > 50 µM; Cyclin-dependent kinase 4: IC50 = >40 µM (human); Fibroblast growth factor receptor 3: IC50 = 60 nM (human); HUVEC50 : IC50 = 100 nM (human); Fibroblast growth factor receptor 2: IC50 = 60 nM (human); C6 : IC50 = >25 µM (rat)
pK Values :
pKa: 10.15, pKb: 2.95
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
1
PubChem CID :
5328127
MDL Number :
MFCD12922514
SMILES :
CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC

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