pan cathepsin Antibody (C-5): sc-365614

Pan cathepsin Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects pan cathepsin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Pan cathepsin encompasses a range of cysteine proteases that play crucial roles in cellular processes such as protein degradation and peptide biosynthesis, which are vital for maintaining cellular homeostasis and regulating metabolic pathways. Notably, these proteases are predominantly localized in lysosomes, where they contribute to the degradation of misfolded or damaged proteins, thus preventing cellular stress and potential apoptosis. The proper functioning of pan cathepsins is essential for various physiological processes, including immune response and tissue remodeling, and dysregulation of these enzymes has been implicated in several diseases, including cancer and neurodegenerative disorders. Pan cathepsin (C-5) antibody provides a powerful tool for researchers aiming to study the expression and activity of these critical proteases in human tissues, facilitating a deeper understanding of their roles in health and disease.

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pan cathepsin Antibody (C-5) References:

1. Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.  |  Franchi, L., et al. 2009. J Innate Immun. 1: 607-17. PMID: 20160900
2. TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.  |  D'Costa, ZC., et al. 2014. Oncotarget. 5: 1609-20. PMID: 24742492
3. Upregulated Autophagy in Sertoli Cells of Ethanol-Treated Rats Is Associated with Induction of Inducible Nitric Oxide Synthase (iNOS), Androgen Receptor Suppression and Germ Cell Apoptosis.  |  Horibe, A., et al. 2017. Int J Mol Sci. 18: PMID: 28505146
4. mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity.  |  Meena, NK., et al. 2018. Immunology. 155: 505-518. PMID: 30144045
5. Hyperbaric oxygen significantly improves frequent urination, hyperalgesia, and tissue damage in a mouse long-lasting cystitis model induced by an intravesical instillation of hydrogen peroxide.  |  Minami, A., et al. 2019. Neurourol Urodyn. 38: 97-106. PMID: 30411813
6. Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy.  |  Eid, N., et al. 2019. Cells. 8: PMID: 30934625
7. Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation.  |  Weiss-Sadan, T., et al. 2019. Mol Cell Proteomics. 18: 1330-1344. PMID: 31010818
8. Molecular probes for selective detection of cysteine cathepsins.  |  Schleyer, KA. and Cui, L. 2021. Org Biomol Chem. 19: 6182-6205. PMID: 34288999
9. Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein.  |  Anderson, A. and Tansey, MG. 2023. bioRxiv.. PMID: 37503267

The preferred pan cathepsin antibody is pan cathepsin Antibody (H-1): sc-376803.