p55 Antibody (A-4): sc-376480

p55 Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects p55 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p55 is an extensively palmitoylated erythrocyte membrane protein and a member of the MAGUK family, known for its critical role in maintaining the structural integrity and functionality of the erythrocyte membrane. p55 (A-4) antibody recognizes a protein structure that includes a PDZ/DHR domain, a conserved SH-3 domain that inhibits the tyrosine kinase activity of various oncoproteins, and a guanylate kinase-like domain, which collectively contribute to its ability to interact with other key proteins such as glycophorin C and 4.1R. These interactions are vital for the dynamic regulation of the erythrocyte membrane, influencing processes such as cell shape and stability. Additionally, p55 gene expression is associated with a CpG island, and p55 is constitutively expressed in K562 erythroleukemia cells during erythropoiesis, showing a two-fold amplification upon induction. anti-p55 antibody (A-4) is an essential tool for researchers studying erythrocyte biology and related pathologies, providing insights into p55′s function and implications in cellular processes.

The preferred p55 antibody is p55 Antibody (A-7): sc-374506.