p-ErbB2/HER2 Antibody (9E10): sc-81509

p-Neu Antibody (9E10) is a mouse monoclonal IgG1 antibody that detects Neu in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). anti-Neu antibody (9E10) specifically recognizes phosphorylated forms of Neu, which is crucial for understanding its role in various signaling pathways associated with cancer progression. Neu, also known as HER2, is a member of the ErbB family of receptor tyrosine kinases and plays a significant role in cell growth and differentiation. Neu is primarily located at the cell membrane, where Neu interacts with other receptors and signaling molecules, facilitating the transduction of extracellular signals that promote cellular proliferation and survival. This localization allows Neu to participate in critical processes such as cell signaling and communication, which are often dysregulated in cancer. Phosphorylation of Neu at specific tyrosine residues, such as Tyr 1248, enhances interaction with downstream signaling proteins like GRB2 and Shc, which are essential for mediating the effects of growth factors. Dysregulation of Neu signaling has been implicated in the development of aggressive forms of breast, gastric, and esophageal cancers, making p-Neu monoclonal antibody (9E10) an important tool for researchers studying these pathways and their implications in tumor biology.

The preferred antibody is Antibody (): sc-8.