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Oxydemeton-methyl (CAS 301-12-2)

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Alternate Names:
Demeton-S-methyl sulfoxide
CAS Number:
301-12-2
Purity:
≥97%
Molecular Weight:
246.28
Molecular Formula:
C6H15O4PS2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Oxydemeton-methyl is an organophosphorus compound known primarily for its use as an insecticide. The environmental persistence and potential toxicity of oxydemeton-methyl to non-target species necessitate the development of sensitive methods for its detection and quantification in environmental samples. Research in this area focuses on improving analytical techniques, such as chromatography and mass spectrometry, to monitor the presence and concentration of oxydemeton-methyl in water bodies, soil, and agricultural products. Oxydemeton-methyl′s mechanism of action involves the inhibition of acetylcholinesterase, an enzyme tasked with the breakdown of the neurotransmitter acetylcholine. By binding to this enzyme, Oxydemeton-methyl effectively impedes its function, halting the normal breakdown of acetylcholine. Consequently, the neurotransmitter accumulates within the system.


Oxydemeton-methyl (CAS 301-12-2) References

  1. An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.  |  Kansal, DK. and Chakrabarti, A. 2000. Indian J Physiol Pharmacol. 44: 57-63. PMID: 10919096
  2. Neurobehavioural study of subchronic administration of oxydemeton-methyl (insecticide and acaricide) in rats.  |  Kansal, DK. and Chakrabarti, A. 2001. Indian J Physiol Pharmacol. 45: 329-36. PMID: 11881572
  3. LC-MS determination of oxydemeton-methyl and its main metabolite demeton-S-methylsulfon in biological specimens--application to a forensic case.  |  Beike, J., et al. 2002. J Anal Toxicol. 26: 308-12. PMID: 12166819
  4. Development of acetylcholinesterase silica sol-gel immobilized biosensor--an application towards oxydemeton methyl detection.  |  Anitha, K., et al. 2004. Biosens Bioelectron. 20: 848-56. PMID: 15522601
  5. Oxydemeton-methyl resistance, mechanisms, and associated fitness cost in green peach aphids (Hemiptera: Aphididae).  |  Ghadamyari, M., et al. 2008. J Econ Entomol. 101: 1432-8. PMID: 18767757
  6. Combined suicide by oxydemeton-methyl (Metasystox) ingestion and hanging.  |  Gottzein, AK., et al. 2009. Forensic Sci Int. 189: e21-5. PMID: 19428202
  7. [Analysis of demeton-S-methyl, oxydemeton-methyl and demeton-S-methylsulfone in agricultural products by LC-MS].  |  Ueno, E., et al. 2009. Shokuhin Eiseigaku Zasshi. 50: 64-9. PMID: 19436153
  8. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning.  |  Eyer, P., et al. 2010. Chem Biol Interact. 187: 270-8. PMID: 19883634
  9. Investigation on diazinon and oxydemeton-methyl residues in cucumbers grown in Kerman greenhouses.  |  Ganjeizadeh Rohani, F., et al. 2014. Environ Monit Assess. 186: 3995-9. PMID: 24526616
  10. Congenital anomalies associated with maternal exposure to oxydemeton-methyl.  |  Romero, P., et al. 1989. Environ Res. 50: 256-61. PMID: 2583071
  11. Interaction of technical hexachlorocyclohexane and oxydemeton methyl 25 EC to female rats after dermal application.  |  Raizada, RB., et al. 1993. Indian J Exp Biol. 31: 142-6. PMID: 7684724
  12. Teratogenesis associated with oxydemeton-methyl in the stage 12 chick embryo.  |  Lenselink, DR., et al. 1993. Teratology. 48: 207-11. PMID: 8248858
  13. Risks from occupational and dietary exposure to mevinphos.  |  Cochran, RC., et al. 1996. Rev Environ Contam Toxicol. 146: 1-24. PMID: 8714219

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Oxydemeton-methyl, 50 mg

sc-257950
50 mg
$294.00